Journal article
Central renin injections: effects on drinking and expression of immediate early genes
Brain research, Vol.782(1), pp.24-35
1998
DOI: 10.1016/S0006-8993(97)01262-6
PMID: 9519246
Abstract
This study investigated the drinking response and the expression of Fos- and Egr-1-immunoreactivity (Fos-ir; Egr-1-ir) in the brain induced by endogenous angiotensin generated by intracerebroventricular (i.c.v.) injection of renin. Renin induced Fos-ir in the subfornical organ (SFO), median preoptic (MnPO), supraoptic and paraventricular nuclei (SON and PVN), area postrema (AP), nuclei of the solitary tract (NTS) and lateral parabrachial nuclei (LPBN). Renin-induced Egr-1-ir exhibited a similar pattern of distribution as that observed for Fos-ir. The dose of i.c.v. renin that induced expression of immediate early gene (IEG) product immunoreactivity also produced vigorous drinking. When renin-injected rats were pretreated with captopril, an angiotensin converting enzyme inhibitor, drinking was blocked. With the same captopril pretreatment, both Fos- and Egr-1-ir in the SFO, MnPO, SON, PVN, AP and LPBN were also significantly reduced.
Details
- Title: Subtitle
- Central renin injections: effects on drinking and expression of immediate early genes
- Creators
- Zhice XuAlan Kim Johnson
- Resource Type
- Journal article
- Publication Details
- Brain research, Vol.782(1), pp.24-35
- Publisher
- Elsevier B.V
- DOI
- 10.1016/S0006-8993(97)01262-6
- PMID
- 9519246
- ISSN
- 0006-8993
- eISSN
- 1872-6240
- Language
- English
- Date published
- 1998
- Academic Unit
- Psychological and Brain Sciences; Neuroscience and Pharmacology; Health and Human Physiology
- Record Identifier
- 9984213431902771
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