Journal article
Central role of dendritic cells in shaping the adaptive immune response during respiratory syncytial virus infection
Future virology, Vol.6(8), pp.963-973
08/2011
DOI: 10.2217/fvl.11.62
PMCID: PMC3163480
PMID: 21887154
Abstract
Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract disease in young children. Premature infants, immunocompromised individuals and the elderly exhibit the highest risk for the development of severe RSV-induced disease. Murine studies demonstrate that CD8 T cells mediate RSV clearance from the lungs. Murine studies also indicate that the host immune response contributes to RSV-induced morbidity as T-cell depletion prevents the development of disease despite sustained viral replication. Dendritic cells (DCs) play a central role in the induction of the RSV-specific adaptive immune response. Following RSV infection, lung-resident DCs acquire viral antigens, migrate to the lung-draining lymph nodes and initiate the T-cell response. This article focuses on data generated from both
in vitro
DC infection studies and RSV mouse models that together have advanced our understanding of how RSV infection modulates DC function and the subsequent impact on the adaptive immune response.
Details
- Title: Subtitle
- Central role of dendritic cells in shaping the adaptive immune response during respiratory syncytial virus infection
- Creators
- Daniel S McDermott - Interdisciplinary Graduate Program in Immunology, 51 Newton Road, 3-532 Bowen Science Building, University of Iowa, Iowa City, IA 52242, USAKayla A Weiss - Interdisciplinary Graduate Program in Immunology, 51 Newton Road, 3-532 Bowen Science Building, University of Iowa, Iowa City, IA 52242, USACory J Knudson - Interdisciplinary Graduate Program in Immunology, 51 Newton Road, 3-532 Bowen Science Building, University of Iowa, Iowa City, IA 52242, USASteven M Varga - Interdisciplinary Graduate Program in Immunology, 51 Newton Road, 3-532 Bowen Science Building, University of Iowa, Iowa City, IA 52242, USA
- Resource Type
- Journal article
- Publication Details
- Future virology, Vol.6(8), pp.963-973
- DOI
- 10.2217/fvl.11.62
- PMID
- 21887154
- PMCID
- PMC3163480
- NLM abbreviation
- Future Virol
- ISSN
- 1746-0794
- eISSN
- 1746-0808
- Grant note
- R01 AI063520-05 || AI / National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID
- Language
- English
- Date published
- 08/2011
- Academic Unit
- Graduate College Admin and Gen; Microbiology and Immunology; Pathology
- Record Identifier
- 9984083272602771
Metrics
24 Record Views