Journal article
Central sensitization and changes in conditioned pain modulation in people with chronic nonspecific low back pain: a case–control study
Experimental brain research, Vol.233(8), pp.2391-2399
08/2015
DOI: 10.1007/s00221-015-4309-6
PMCID: PMC4679196
PMID: 25963754
Abstract
Quantitative sensory testing is widely used in human research to investigate the state of the peripheral and central nervous system contributions in pain processing. It is a valuable tool to help identify central sensitization and may be important in the treatment of low back pain. The aim of this study was to evaluate changes in local and segmental hypersensitivity and endogenous pain inhibition in people with chronic nonspecific low back pain. Thirty patients with chronic low back pain and thirty healthy subjects were studied. Pressure pain thresholds (PPTs) were measured from the lumbar region and over the tibialis anterior muscle (TA). A cold pressor test was used to assess the activation of conditioned pain modulation (CPM), and PPTs in the lumbar region were recorded 30 s after immersion of participant’s foot in a bucket with cold water. People with chronic low back pain have significantly lower PPT than controls at both the lumbar region [89.5 kPa (mean difference) 95 % CI 40.9–131.1 kPa] and TA [59.45 kPa (mean difference) 95 % CI 13.49–105.42 kPa]. During CPM, people with chronic low back pain have significantly lower PPT than controls in lumbar region [118.6 kPa (mean difference) 95 % CI 77.9–159.2 kPa]. Women had significantly lower PPTs than men in both lumbar region [101.7 kPa (mean difference) 95 % CI 37.9–165.7 kPa] and over the TA [189.7 kPa (mean difference) 95 % CI 14.2–145.2 kPa]. There was no significant difference in PPTs in men between healthy controls and those with low back pain, suggesting the significant differences are mediated primarily by difference between women.
Details
- Title: Subtitle
- Central sensitization and changes in conditioned pain modulation in people with chronic nonspecific low back pain: a case–control study
- Creators
- Juliana Barbosa Corrêa - Master’s and Doctoral Programs in Physical Therapy, Universidade Cidade de São Paulo, Rua Cesário Galeno 448, Tatuapé, São Paulo CEP 03071-000, BrazilLeonardo Oliveira Pena Costa - Master’s and Doctoral Programs in Physical Therapy, Universidade Cidade de São Paulo, Rua Cesário Galeno 448, Tatuapé, São Paulo CEP 03071-000, BrazilNaiane Teixeira Bastos de Oliveira - Master’s and Doctoral Programs in Physical Therapy, Universidade Cidade de São Paulo, Rua Cesário Galeno 448, Tatuapé, São Paulo CEP 03071-000, BrazilKathleen A Sluka - Graduate Program in Physical Therapy and Rehabilitation Science, College of Medicine, University of Iowa, Iowa City, IA, USARichard Eloin Liebano - Master’s and Doctoral Programs in Physical Therapy, Universidade Cidade de São Paulo, Rua Cesário Galeno 448, Tatuapé, São Paulo CEP 03071-000, Brazil
- Resource Type
- Journal article
- Publication Details
- Experimental brain research, Vol.233(8), pp.2391-2399
- DOI
- 10.1007/s00221-015-4309-6
- PMID
- 25963754
- PMCID
- PMC4679196
- NLM abbreviation
- Exp Brain Res
- ISSN
- 0014-4819
- eISSN
- 1432-1106
- Grant note
- DOI: 10.13039/501100001807, name: Fundação de Amparo à Pesquisa do Estado de São Paulo, award: 2012/13910-2; DOI: 10.13039/501100003593, name: Conselho Nacional de Desenvolvimento Científico e Tecnológico, award: 473929/2012-0
- Language
- English
- Date published
- 08/2015
- Academic Unit
- Iowa Neuroscience Institute; Nursing; Physical Therapy and Rehabilitation Science; Neuroscience and Pharmacology
- Record Identifier
- 9984040385302771
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