Journal article
Centrally administered non-NMDA but not NMDA receptor antagonists block peripheral knee joint inflammation
Pain (Amsterdam), Vol.55(2), pp.217-225
11/1993
DOI: 10.1016/0304-3959(93)90150-N
PMID: 7906027
Abstract
An experimental arthritis of the knee joint resulted in limping, guarding, and an increased response to heat stimuli (heat hyperalgesia). Spinal administration of the non-N-methyl-D-aspartate (non-NMDA) antagonist, 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX), significantly reduced the degree of peripheral inflammation, thermal and behavioral manifestations of arthritis. NMDA antagonists had no effect on the inflammation but did prevent the development of the heat hyperalgesia. Thus, central non-NMDA receptors play a major role in the development of peripheral inflammation while both non-NMDA and NMDA receptors are involved in the development of heat hyperalgesia.
Details
- Title: Subtitle
- Centrally administered non-NMDA but not NMDA receptor antagonists block peripheral knee joint inflammation
- Creators
- K A Sluka - Department of Anatomy and Neurosciences, University of Texas Medical Branch, Galveston 77555K N Westlund
- Resource Type
- Journal article
- Publication Details
- Pain (Amsterdam), Vol.55(2), pp.217-225
- Publisher
- United States
- DOI
- 10.1016/0304-3959(93)90150-N
- PMID
- 7906027
- ISSN
- 0304-3959
- eISSN
- 1872-6623
- Grant note
- NS01445 / NINDS NIH HHS R01 NS28064 / NINDS NIH HHS NS11255 / NINDS NIH HHS
- Language
- English
- Date published
- 11/1993
- Academic Unit
- Iowa Neuroscience Institute; Nursing; Physical Therapy and Rehabilitation Science; Neuroscience and Pharmacology
- Record Identifier
- 9984040244402771
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