Journal article
Cephalic angiotensin receptors mediating drinking to systemic angiotensin II
Pharmacology, biochemistry and behavior, Vol.3(6), pp.1077-1084
1975
DOI: 10.1016/0091-3057(75)90020-9
PMID: 177996
Abstract
In rats implanted with cannulae to allow delivery of solutions to the cerebral ventricular system, pretreatment with 5 μg or 0.5 μg of saralasin acetate (Sar
1 Ala
8 Angiotensin II), an angiotensin II competitive analog, significantly attenuated drinking to subcutaneous (SC) injections of 500 μg of angiotensin II. However, pretreatment with either SC (5 μg or 20 μg) or with intravenous (5 μg) saralasin had no effect on drinking to SC angiotensin II (500 μg). Intracranial (IC) injections of 5 μg of saralasin had no effect on drinking in response to SC injections of 0.8 cc of a 10 percent NaCl solution and did not attenuate ingestion of a milk solution in a dessert test. On the basis of the specificity and the greater efficacy shown by IC saralasin in attenuating drinking to systemically applied angiotensin II, it was concluded that circulating angiotensin II reaches brain periventricular receptors which mediate drinking.
Details
- Title: Subtitle
- Cephalic angiotensin receptors mediating drinking to systemic angiotensin II
- Creators
- Alan Kim JohnsonJames E Schwob
- Resource Type
- Journal article
- Publication Details
- Pharmacology, biochemistry and behavior, Vol.3(6), pp.1077-1084
- Publisher
- Elsevier Inc
- DOI
- 10.1016/0091-3057(75)90020-9
- PMID
- 177996
- ISSN
- 0091-3057
- eISSN
- 1873-5177
- Language
- English
- Date published
- 1975
- Academic Unit
- Psychological and Brain Sciences; Neuroscience and Pharmacology; Health and Human Physiology
- Record Identifier
- 9984214760202771
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