Journal article
Cercophorins A−C: Novel Antifungal and Cytotoxic Metabolites from the Coprophilous Fungus Cercophora areolata
Journal of natural products (Washington, D.C.), Vol.59(8), pp.765-769
08/22/1996
DOI: 10.1021/np9603232
PMID: 8792624
Abstract
Cercophorins A-C (3-5), three novel isocoumarin derivatives with antifungal and cytotoxic activities, have been isolated from the coprophilous fungus Cercophora areolata (JS 166 = UAMH 7495), a colonist of porcupine dung. Two additional new isocoumarins, decarboxycitrinone (1) and 4-acetyl- 8-hydroxy-6-methoxy-5-methylisocoumarin (2), and a known tricothecene mycotoxin, roridin E (6), were also obtained from this species. Compounds 1- 6 were isolated from ethyl acetate extracts of mycelia and liquid cultures of C. areolata through bioassay-guided fractionation and are the first metabolites to be reported from a member of the genus Cercophora. Their structures were assigned on the basis of MS, selective INEPT, and 2D-NMR experiments.
Details
- Title: Subtitle
- Cercophorins A−C: Novel Antifungal and Cytotoxic Metabolites from the Coprophilous Fungus Cercophora areolata
- Creators
- Authrine C Whyte - Department of Chemistry, University of Iowa, Iowa City, Iowa 52242James B Gloer - Department of Chemistry, University of Iowa, Iowa City, Iowa 52242James A Scott - Department of Chemistry, University of Iowa, Iowa City, Iowa 52242David Malloch - Department of Chemistry, University of Iowa, Iowa City, Iowa 52242
- Resource Type
- Journal article
- Publication Details
- Journal of natural products (Washington, D.C.), Vol.59(8), pp.765-769
- Publisher
- American Chemical Society
- DOI
- 10.1021/np9603232
- PMID
- 8792624
- ISSN
- 0163-3864
- eISSN
- 1520-6025
- Language
- English
- Date published
- 08/22/1996
- Academic Unit
- Chemistry
- Record Identifier
- 9984216704202771
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