Journal article
Cerebellar Contributions to Motor Impairments in People with Multiple Sclerosis
Cerebellum (London, England), Vol.21, pp.1052-1060
2022
DOI: 10.1007/s12311-021-01336-6
PMID: 34657272
Abstract
Although Charcot characterized classic cerebellar symptoms in people with multiple sclerosis (PwMS) in 1877, the impact of cerebellar dysfunction on MS symptoms has predominately been evaluated in the last two decades. Recent studies have clearly demonstrated the association between cerebellar pathology, including atrophy and reduced fractional anisotropy in the peduncles, and motor impairments, such as reduced gait velocity and time to complete walking tasks. However, future studies using novel imaging techniques are needed to elucidate all potential pathophysiology that is associated with disability in PwMS. Additionally, future studies are required to determine the most effective treatments for motor impairments in PwMS, including the specific type and duration of exercise interventions, and potential means to amplify their effects, such as transcranial direct current stimulation (tDCS). This mini-review critically discusses the distinct role of cerebellar dysfunction in motor impairments in PwMS, potential treatments, and directions for future studies.
Details
- Title: Subtitle
- Cerebellar Contributions to Motor Impairments in People with Multiple Sclerosis
- Creators
- Alexandra C. Fietsam - University of IowaWarren G. Darling - University of IowaJacob J. Sosnoff - University of KansasCraig D. Workman - University of IowaJohn Kamholz - University of IowaThorsten Rudroff - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Cerebellum (London, England), Vol.21, pp.1052-1060
- Publisher
- Springer Nature
- DOI
- 10.1007/s12311-021-01336-6
- PMID
- 34657272
- ISSN
- 1473-4222
- eISSN
- 1473-4230
- Number of pages
- 9
- Language
- English
- Electronic publication date
- 10/17/2021
- Date published
- 2022
- Academic Unit
- Neurology; Psychiatry; Physical Therapy and Rehabilitation Science; Health and Human Physiology
- Record Identifier
- 9984259393302771
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