Journal article
Cerebellar Oscillatory Patterns in Essential Tremor: Modulatory Effects of VIM-DBS
Cerebellum (London, England), Vol.24(2), 40
04/01/2025
DOI: 10.1007/s12311-025-01787-1
PMCID: PMC11787153
PMID: 39891875
Abstract
Essential tremor (ET) is a common movement disorder, and while ventral intermediate nucleus deep brain stimulation (VIM-DBS) is a well-established treatment, its precise mechanisms or modulatory effects, particularly in relation to cerebellar oscillations, remain unclear. In this study, we hypothesized that VIM-DBS would modulate cerebellar oscillatory activity across both resting and motor task conditions, reflecting its impact on cerebello-thalamic pathways. Ten patients diagnosed with ET participated in this study. We examined the effects of VIM-DBS on mid-cerebellar oscillations during resting-state and lower-limb pedaling motor tasks. Frequency analysis was conducted on the resting-state signal and time-frequency analysis was performed on motor task-related signals. We explored the modulatory effects of VIM-DBS on oscillatory activity across delta, theta, alpha, beta, and gamma frequency bands. We found that ON VIM-DBS increased mid-cerebellar relative theta power during resting-state conditions, with no significant changes in other frequency bands. During a pedaling motor task, VIM-DBS led to significant reductions in theta, alpha, and gamma power, highlighting the frequency-specific effects of stimulation. VIM-DBS also increased peak acceleration of leg movements during the pedaling task. Furthermore, VIM-DBS selectively increased mid-frontal relative theta and beta power as well as mid-occipital relative theta power during resting condition, suggesting localized mid-cerebellar modulation. Moreover, similarity analyses between mid-cerebellar and nearby mid-occipital signals revealed differences in coherence, phase coherence, and cross-spectrum phase coherence. Overall, these results support the role of VIM-DBS in modulating mid-cerebellar oscillations in ET and provide new insights into the neural mechanisms underlying DBS efficacy.
Details
- Title: Subtitle
- Cerebellar Oscillatory Patterns in Essential Tremor: Modulatory Effects of VIM-DBS
- Creators
- Taylor J. Bosch - University of South DakotaChristopher Groth - University of IowaArturo I. Espinoza - University of IowaVishal Bharmauria - University of South FloridaOliver Flouty - University of South FloridaArun Singh - University of South Dakota
- Resource Type
- Journal article
- Publication Details
- Cerebellum (London, England), Vol.24(2), 40
- Publisher
- Springer US
- DOI
- 10.1007/s12311-025-01787-1
- PMID
- 39891875
- PMCID
- PMC11787153
- ISSN
- 1473-4222
- eISSN
- 1473-4230
- Language
- English
- Date published
- 04/01/2025
- Academic Unit
- Neurology
- Record Identifier
- 9984781373302771
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