Journal article
Cerebellar large B-cell lymphoma: a case report
Journal of medical case reports, Vol.12(1), pp.341-341
11/17/2018
DOI: 10.1186/s13256-018-1880-z
PMCID: PMC6240289
PMID: 30446015
Abstract
Primary central nervous system lymphoma is a rare, malignant non-Hodgkin lymphoma that can arise in the brain, spinal cord, eye, leptomeninges, or cranial nerves. Primary central nervous system lymphoma is rare, accounting for 2-6% of all primary brain neoplasms and 1-2% of all non-Hodgkin lymphomas, and it usually presents as a solitary lesion. Cerebellar involvement is present in only 9% of cases. We present an unusual case of primary central nervous system lymphoma presenting as multiple lesions in the cerebellum in an immunocompetent host.
A 71-year-old Caucasian man presented to our hospital with acute onset of dizziness, nausea, vomiting, and gait imbalance. Contrast-enhanced computed tomography revealed three intensely enhancing masses in the right cerebellar hemisphere. Whole-body positron emission tomography and computed tomography failed to demonstrate a primary tumor of origin outside the central nervous system. The patient underwent right suboccipital craniotomy with partial resection of the visible tumor from the right cerebellum. Histopathology revealed diffuse large B-cell lymphoma, non-germinal center type.
Primary central nervous system lymphoma is rare, even more so in the cerebellum. However, the overall incidence of primary central nervous system lymphoma is rising in both immunocompromised and immunocompetent patients. The highly aggressive nature of primary central nervous system lymphoma necessitates timely diagnosis and intervention. In this report, we review the available literature for a better understanding of the pathophysiology and management of primary central nervous system lymphoma. To the best of our knowledge, this is the first reported case of a patient with primary central nervous system lymphoma presenting with multiple masses in the cerebellum.
Details
- Title: Subtitle
- Cerebellar large B-cell lymphoma: a case report
- Creators
- Malik Ghannam - University of MinnesotaShaden Mansour - An-Najah National UniversityFareed Jumah - An-Najah National UniversityBrent Berry - University of MinnesotaAlbertine Beard - Minneapolis VA Health Care System
- Resource Type
- Journal article
- Publication Details
- Journal of medical case reports, Vol.12(1), pp.341-341
- DOI
- 10.1186/s13256-018-1880-z
- PMID
- 30446015
- PMCID
- PMC6240289
- ISSN
- 1752-1947
- eISSN
- 1752-1947
- Language
- English
- Date published
- 11/17/2018
- Academic Unit
- Neurology
- Record Identifier
- 9984585427502771
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