Journal article
Cerebellar signatures of vestibulo-ocular reflex motor learning
The Journal of neuroscience, Vol.23(30), pp.9742-9751
10/29/2003
DOI: 10.1523/jneurosci.23-30-09742.2003
PMCID: PMC6740887
PMID: 14586001
Abstract
The vestibulo-ocular reflex (VOR) comprises an outstanding system to perform studies that probe possible cerebellar roles in motor learning. Novel VOR gains can be induced (learned) by the wearing of minifying or magnifying lenses, and learning requires the presence of the cerebellum. Previously, it was shown that Purkinje cells change their head velocity sensitivities with learning and that this change was thought to be inappropriate to be causal for the changed behavior. We now demonstrate that Purkinje cells also change their eye position, eye velocity, and head velocity sensitivities after learning. These combined changes at the Purkinje cell level contribute to a net modulation that is appropriate to support the new VOR gains. Importantly, the changes in the eye position parameter, reported for the first time, suggest the involvement of the neuronal integrator pathways in VOR learning. We provide evidence that all of these changes are necessary for VOR behavior and can explain learning deficits after cerebellar removal.
Details
- Title: Subtitle
- Cerebellar signatures of vestibulo-ocular reflex motor learning
- Creators
- Pablo M Blazquez - Chubu UniversityYutaka Hirata - Chubu UniversityShane A Heiney - Chubu UniversityAndrea M Green - Chubu UniversityStephen M Highstein - Chubu University
- Resource Type
- Journal article
- Publication Details
- The Journal of neuroscience, Vol.23(30), pp.9742-9751
- DOI
- 10.1523/jneurosci.23-30-09742.2003
- PMID
- 14586001
- PMCID
- PMC6740887
- ISSN
- 0270-6474
- eISSN
- 1529-2401
- Language
- English
- Date published
- 10/29/2003
- Academic Unit
- Iowa Neuroscience Institute; Neuroscience and Pharmacology
- Record Identifier
- 9984622055502771
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