Cerebellum Structure Differences and Relationship to Speech in Boys and Girls with Nonsyndromic Cleft of the Lip and/or Palate

Amy L Conrad; Scott Dailey; Lynn Richman; John Canady; Michael P Karnell; Eric Axelson; Peg Nopoulos

doi:10.1597/08-228

Back

Cerebellum Structure Differences and Relationship to Speech in Boys and Girls with Nonsyndromic Cleft of the Lip and/or Palate

Journal article

Open access

Peer reviewed

Cerebellum Structure Differences and Relationship to Speech in Boys and Girls with Nonsyndromic Cleft of the Lip and/or Palate

Amy L Conrad, Scott Dailey, Lynn Richman, John Canady, Michael P Karnell, Eric Axelson and Peg Nopoulos

The Cleft palate-craniofacial journal, Vol.47(5), pp.469-475

09/2010

DOI: 10.1597/08-228

PMCID: PMC3218570

PMID: 20180711

Files and links (1)

url

https://www.ncbi.nlm.nih.gov/pmc/articles/3218570View

Open Access

Abstract

Objective: To identify regional cerebellar structural differences in boys and girls with nonsyndromic cleft of the lip and/or palate and determine whether these differences are related to speech impairment. Design: Between 2003 and 2007, measures on cerebellar volume were obtained on 43 children with nonsyndromic cleft of the lip and/or palate and 43 age- and sex-matched, healthy controls. Children with the cleft condition also received speech evaluations. Children with nonsyndromic cleft of the lip and/or palate were recruited from clinic records, and controls (screened for medical, psychiatric, speech/language, and behavioral concerns) were recruited from the local community. All tests were administered at a large midwestern hospital. Boys and girls with nonsyndromic cleft of the lip and/or palate were compared with the healthy controls on global and regional measures of cerebellar volume. Areas of significant difference were then correlated with measures of speech to assess relationships in children with nonsyndromic cleft of the lip and/or palate. Results: Boys with nonsyndromic cleft of the lip and/or palate had smaller cerebellums than controls (p = .002); whereas, for girls, only regional reductions in size reached significance (corpus medullare, p = .040). Cerebellum size was correlated with articulation for boys (p = .045). Conclusions: These findings lend support to previous research documenting abnormal brain structure in children with nonsyndromic cleft of the lip and/or palate and suggest that the cerebellum may play a role in speech deficits along with other structural causes, at least in boys.

Details

Title: Subtitle: Cerebellum Structure Differences and Relationship to Speech in Boys and Girls with Nonsyndromic Cleft of the Lip and/or Palate
Creators: Amy L Conrad - Department of Psychiatry Research, University of Iowa College of Medicine, Iowa City, Iowa
Scott Dailey - Speech-Language Pathologist, Department of Otolaryngology
Lynn Richman - Department of Pediatrics
John Canady - Department of Otolaryngology
Michael P Karnell - Department of Otolaryngology and Department of Communication Sciences & Disorders, University of Iowa Hospitals and Clinics, Iowa City, Iowa
Eric Axelson - Department of Psychiatry Research, University of Iowa College of Medicine, Iowa City, Iowa
Peg Nopoulos - Department of Psychiatry Research, University of Iowa College of Medicine, Iowa City, Iowa
Resource Type: Journal article
Publication Details: The Cleft palate-craniofacial journal, Vol.47(5), pp.469-475
DOI: 10.1597/08-228
PMID: 20180711
PMCID: PMC3218570
NLM abbreviation: Cleft Palate Craniofac J
ISSN: 1055-6656
eISSN: 1545-1569
Language: English
Date published: 09/2010
Academic Unit: Neurology; Communication Sciences and Disorders; Psychiatry; Pediatric Psychology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Craniofacial Anomalies Research Center; Otolaryngology
Record Identifier: 9984004189402771

Metrics

93 Record Views

30 Times Cited - Web of Science