Journal article
Cerebral Artery Velocity Determined by Transcranial Doppler Ultrasonography in Patients With -Thalassemia Intermedia Compared to -Thalassemia Major
Clinical and applied thrombosis/hemostasis, Vol.19(4), pp.367-373
07/01/2013
DOI: 10.1177/1076029612461068
PMID: 23104954
Abstract
We aimed to compare cerebral artery velocity and relevant clinical factors in patients with -thalassemia intermedia (-TI), -thalassemia major (-TM), and healthy individuals. For this study, 60 patients with -TM and 64 with -TI were randomly selected. Sixty healthy adults comprised the control group. Time average maximum mean velocity (TAMMV) was measured in large cerebral arteries with transcranial Doppler (TCD) ultrasonography. In all arteries, TAMMV was significantly higher in the -TI group than that of -TM or controls (P < .001). Patients with -TM had significantly higher TAMMV than controls in most arteries evaluated (P < .001). Overall, the lack of regular blood transfusions, splenectomy, and lower age (to a lesser extent) was found to be independent influencing factors contributing to high cerebral artery velocities. Further detailed longitudinal studies are needed to confirm these results and to determine the risk of silent infarction and stroke in patients with thalassemia and abnormal TCD, with particular focus on patients with -TI.
Details
- Title: Subtitle
- Cerebral Artery Velocity Determined by Transcranial Doppler Ultrasonography in Patients With -Thalassemia Intermedia Compared to -Thalassemia Major
- Creators
- Mehran Karimi - Shiraz University of Medical SciencesSezaneh Haghpanah - Shiraz University of Medical SciencesNahid Ashjazadeh - Shiraz University of Medical SciencesAbdolhamid Shariat - Shiraz University of Medical SciencesMasoume Nazeri - Shiraz University of Medical SciencesSajad Emami - Shiraz University of Medical SciencesAmin Abolhasani Forough - Shiraz UniversityPeyman Petramfar - Shiraz University of Medical SciencesEhsan Yaghoubi - Shiraz University of Medical Sciences
- Resource Type
- Journal article
- Publication Details
- Clinical and applied thrombosis/hemostasis, Vol.19(4), pp.367-373
- DOI
- 10.1177/1076029612461068
- PMID
- 23104954
- NLM abbreviation
- Clin Appl Thromb Hemost
- ISSN
- 1076-0296
- eISSN
- 1938-2723
- Publisher
- Sage
- Number of pages
- 7
- Grant note
- Vice Chancellery for Research of Shiraz University of Medical Sciences; Isfahan University of Medical Sciences
- Language
- English
- Date published
- 07/01/2013
- Academic Unit
- Neurology
- Record Identifier
- 9985013729402771
Metrics
4 Record Views