Journal article
Cerebral Vascular Disease and Neurovascular Injury in Ischemic Stroke
Circulation research, Vol.120(3), pp.449-471
02/03/2017
DOI: 10.1161/CIRCRESAHA.116.308427
PMCID: PMC5313039
PMID: 28154097
Abstract
The consequences of cerebrovascular disease are among the leading health issues worldwide. Large and small cerebral vessel disease can trigger stroke and contribute to the vascular component of other forms of neurological dysfunction and degeneration. Both forms of vascular disease are driven by diverse risk factors, with hypertension as the leading contributor. Despite the importance of neurovascular disease and subsequent injury after ischemic events, fundamental knowledge in these areas lag behind our current understanding of neuroprotection and vascular biology in general. The goal of this review is to address select key structural and functional changes in the vasculature that promote hypoperfusion and ischemia, while also affecting the extent of injury and effectiveness of therapy. In addition, as damage to the blood-brain barrier is one of the major consequences of ischemia, we discuss cellular and molecular mechanisms underlying ischemia-induced changes in blood-brain barrier integrity and function, including alterations in endothelial cells and the contribution of pericytes, immune cells, and matrix metalloproteinases. Identification of cell types, pathways, and molecules that control vascular changes before and after ischemia may result in novel approaches to slow the progression of cerebrovascular disease and lessen both the frequency and impact of ischemic events.
Details
- Title: Subtitle
- Cerebral Vascular Disease and Neurovascular Injury in Ischemic Stroke
- Creators
- Xiaoming Hu - From the Pittsburgh Institute of Brain Disorders and Recovery, University of Pittsburgh School of Medicine, PA (X.H., J.C.); Biomedicine Discovery Institute, Department of Pharmacology, Monash University, Clayton, Victoria, Australia (T.M.D.S.); and Departments of Internal Medicine and Pharmacology, Carver College of Medicine, University of Iowa, Iowa City Veterans Affairs Healthcare System (F.M.F.)T Michael De Silva - From the Pittsburgh Institute of Brain Disorders and Recovery, University of Pittsburgh School of Medicine, PA (X.H., J.C.); Biomedicine Discovery Institute, Department of Pharmacology, Monash University, Clayton, Victoria, Australia (T.M.D.S.); and Departments of Internal Medicine and Pharmacology, Carver College of Medicine, University of Iowa, Iowa City Veterans Affairs Healthcare System (F.M.F.)Jun Chen - University of PittsburghFrank M Faraci - From the Pittsburgh Institute of Brain Disorders and Recovery, University of Pittsburgh School of Medicine, PA (X.H., J.C.); Biomedicine Discovery Institute, Department of Pharmacology, Monash University, Clayton, Victoria, Australia (T.M.D.S.); and Departments of Internal Medicine and Pharmacology, Carver College of Medicine, University of Iowa, Iowa City Veterans Affairs Healthcare System (F.M.F.). frank-faraci@uiowa.edu ChenJ2@upmc.edu
- Resource Type
- Journal article
- Publication Details
- Circulation research, Vol.120(3), pp.449-471
- DOI
- 10.1161/CIRCRESAHA.116.308427
- PMID
- 28154097
- PMCID
- PMC5313039
- NLM abbreviation
- Circ Res
- ISSN
- 0009-7330
- eISSN
- 1524-4571
- Publisher
- United States
- Grant note
- R01 NS045048 / NINDS NIH HHS R01 NS089534 / NINDS NIH HHS I01 BX001399 / BLRD VA R01 HL113863 / NHLBI NIH HHS R01 NS092618 / NINDS NIH HHS I01 BX002495 / BLRD VA P01 HL062984 / NHLBI NIH HHS R01 NS091175 / NINDS NIH HHS R01 NS095671 / NINDS NIH HHS R01 NS096465 / NINDS NIH HHS
- Language
- English
- Date published
- 02/03/2017
- Academic Unit
- Cardiovascular Medicine; Neuroscience and Pharmacology; Internal Medicine
- Record Identifier
- 9984040435002771
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