Journal article
Cerebral Vascular Responses to Physiological Stimulation of Sympathetic Pathways in Cats
Circulation research, Vol.44(2), pp.288-294
02/1979
DOI: 10.1161/01.RES.44.2.288
PMID: 761309
Abstract
This study was designed to determine whether physiological activation of sympathetic pathways affects cerebral blood flow (CBF) and the integrity of the blood-brain barrier during hypertension. Increased sympathetic activity was induced in anesthetized cats by sinoaortic deafferentation (SAD), a procedure that results in acute, severe neurogenic hypertension. Sympathetic innervation of one cerebral hemisphere was interrupted by sectioning the superior cervical ganglion or the cervical sympathetic trunk. CBF was measured with microspheres, and disruption of the blood-brain barrier was evaluated using Evans blue dye. Following SAD, mean arterial pressure increased abruptly from 142 ± 8 (mean ± SE) to 226 ± 9 mm Hg, and total CBF increased from 31 ± 2 to 99 ± 15 ml/min per 100 g. Blood flow and the extent of disruption of the blood-brain barrier were less in the innervated hemibrain than in the denervated hemibrain. The influence of sympathetic nerves was most pronounced in cortical gray matterblood flow was 24 ± 4% less (P < 0.05) in the cortical gray matter of the innervated hemibrain 1 minute following SAD. Additional studies were performed to determine whether physiological stimulation of sympathetic nerves constricts cerebral vessels during hemorrhagic hypotension in cats. During hypotension, blood flow was significantly lower in several regions of the innervated hemibrain compared to the denervated hemibrain, but the effect was very small. These results provide evidence for neural regulation of CBF when sympathetic tone is augmented by physiological stimuli during acute hypertension and hypotension. The data represent the first demonstration of a reduction in CBF when sympathetic nerves are activated physiologically during acute severe hypertension. cire Res 44288-294, 1979
Details
- Title: Subtitle
- Cerebral Vascular Responses to Physiological Stimulation of Sympathetic Pathways in Cats
- Creators
- PAUL GROSS - From the Cardiovascular Division, Department of Internal Medicine, Department of Pharmacology, and the Cardiovascular Center, University of Iowa College of Medicine, and Veterans Administration Hospital, Iowa City, IowaDONALD HEISTADM STRAITMELVIN MARCUSMICHAEL BRODY
- Resource Type
- Journal article
- Publication Details
- Circulation research, Vol.44(2), pp.288-294
- DOI
- 10.1161/01.RES.44.2.288
- PMID
- 761309
- NLM abbreviation
- Circ Res
- ISSN
- 0009-7330
- eISSN
- 1524-4571
- Publisher
- American Heart Association, Inc
- Language
- English
- Date published
- 02/1979
- Academic Unit
- Cardiovascular Medicine; Neuroscience and Pharmacology; Internal Medicine
- Record Identifier
- 9984040591102771
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