Cerebral aneurysms: formation, progression, and developmental chronology

Nima Etminan; Bruce A Buchholz; Rita Dreier; Peter Bruckner; James C Torner; Hans-Jakob Steiger; Daniel Hänggi; R Loch Macdonald

doi:10.1007/s12975-013-0294-x

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Cerebral aneurysms: formation, progression, and developmental chronology

Journal article

Open access

Peer reviewed

Cerebral aneurysms: formation, progression, and developmental chronology

Nima Etminan, Bruce A Buchholz, Rita Dreier, Peter Bruckner, James C Torner, Hans-Jakob Steiger, Daniel Hänggi and R Loch Macdonald

Translational stroke research, Vol.5(2), pp.167-173

04/2014

DOI: 10.1007/s12975-013-0294-x

PMCID: PMC4399795

PMID: 24323717

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Abstract

The prevalence of unruptured intracranial aneurysms (UIAs) in the general population is up to 3%. Existing epidemiological data suggests that only a small fraction of UIAs progress towards rupture over the lifetime of an individual, but the surrogates for subsequent rupture and the natural history of UIAs are discussed very controversially at present. In case of rupture of an UIA, the case fatality is up to 50%, which therefore continues to stimulate interest in the pathogenesis of cerebral aneurysm formation and progression. Actual data on the chronological development of cerebral aneurysm has been especially difficult to obtain and, until recently, the existing knowledge in this respect is mainly derived from animal or mathematical models or short-term observational studies. Here, we review the current data on cerebral aneurysm formation and progression as well as a novel approach to investigate the developmental chronology of cerebral aneurysms.

Models, Theoretical

Intracranial Aneurysm - etiology

Intracranial Aneurysm - pathology

Humans

Risk Factors

Disease Progression

Details

Title: Subtitle: Cerebral aneurysms: formation, progression, and developmental chronology
Creators: Nima Etminan - Department of Neurosurgery, Medical Faculty, Heinrich-Heine-University, Moorenstrasse 5, 40225, Dusseldorf, Germany, etminan@uni-duesseldorf.de
Bruce A Buchholz
Rita Dreier
Peter Bruckner
James C Torner
Hans-Jakob Steiger
Daniel Hänggi
R Loch Macdonald
Resource Type: Journal article
Publication Details: Translational stroke research, Vol.5(2), pp.167-173
DOI: 10.1007/s12975-013-0294-x
PMID: 24323717
PMCID: PMC4399795
NLM abbreviation: Transl Stroke Res
ISSN: 1868-4483
eISSN: 1868-601X
Publisher: United States
Grant note: P41 GM103483 / NIGMS NIH HHS 8P41GM103483 / NIGMS NIH HHS Canadian Institutes of Health Research
Language: English
Date published: 04/2014
Academic Unit: Epidemiology; Surgery; Injury Prevention Research Center; Neurosurgery
Record Identifier: 9983995120802771

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