Journal article
Cerebral circulation: humoral regulation and effects of chronic hypertension
Journal of the American Society of Nephrology, Vol.1(1), pp.53-57
07/1990
DOI: 10.1681/ASN.V1153
PMID: 2104251
Abstract
New concepts have emerged in recent years concerning regulation of cerebral circulation. The purpose of this review is to summarize briefly several of these concepts. First, humoral mechanisms may have important effects on cerebral blood vessels and blood flow to choroid plexus. Recent evidence suggests that several vasoactive peptides may have major effects on fluid and ion balance in the brain by altering blood flow to the choroid plexus and possibly the production of cerebrospinal fluid. Second, chronic hypertension produces structural remodeling and hypertrophy of cerebral blood vessels and a shift in the relationship of cerebral blood flow to systemic blood pressure. Third, endothelium-dependent responses of cerebral arterioles to receptor and nonreceptor mediated agonists are impaired during chronic hypertension. Alterations in endothelium-dependent responses of cerebral arterioles during chronic hypertension appears to be due to release of an endothelium-derived contracting factor.
Details
- Title: Subtitle
- Cerebral circulation: humoral regulation and effects of chronic hypertension
- Creators
- F M Faraci - Department of Internal Medicine, University of Iowa College of Medicine, Iowa City 52242G L BaumbachD D Heistad
- Resource Type
- Journal article
- Publication Details
- Journal of the American Society of Nephrology, Vol.1(1), pp.53-57
- Publisher
- United States
- DOI
- 10.1681/ASN.V1153
- PMID
- 2104251
- ISSN
- 1046-6673
- eISSN
- 1533-3450
- Grant note
- HL-16066 / NHLBI NIH HHS HL-38901 / NHLBI NIH HHS NS-24621 / NINDS NIH HHS
- Language
- English
- Date published
- 07/1990
- Academic Unit
- Pathology; Cardiovascular Medicine; Fraternal Order of Eagles Diabetes Research Center; Neuroscience and Pharmacology; Internal Medicine
- Record Identifier
- 9984040440702771
Metrics
23 Record Views