Cerebral perfusion reserve indexes determined by fluoromethane positron emission scanning

R. L LEVINE; J. J SUNDERLAND; H. L LAGREZE; R. J NICKLES; B. R ROWE; P. A TURSKI

doi:10.1161/01.STR.19.1.19

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Cerebral perfusion reserve indexes determined by fluoromethane positron emission scanning

Journal article

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Cerebral perfusion reserve indexes determined by fluoromethane positron emission scanning

R. L LEVINE, J. J SUNDERLAND, H. L LAGREZE, R. J NICKLES, B. R ROWE and P. A TURSKI

Stroke (1970), Vol.19(1), pp.19-27

1988

DOI: 10.1161/01.STR.19.1.19

PMID: 3122375

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Abstract

An index of cerebral perfusion reserve (RES%), defined as the percent change of regional cerebral blood flow over baseline per mm Hg of end-tidal CO2 tension, was determined for each middle cerebral artery (MCA) territory in patients with unilateral carotid distribution transient ischemic attacks or minor cerebrovascular accidents and was compared with that of age-matched, neurologically normal volunteers. Vasodilator responses to induced hypercapnia were tested during inhalation of 5% CO2 in 95% O2 while regional cerebral blood flow was measured by fluoromethane inhalation positron emission tomography. Mean RES% for 24 normal MCA territories was 5.2 +/- 0.8%. Mean RES% for 15 patient nonischemic MCA territories was 3.8 +/- 1.3% and for 15 ischemic MCA territories was 2.8 +/- 1.9% (both p less than 0.001). Individual RES% values and symmetry ratios between ischemic and nonischemic regions were also determined and compared with angiographic data. Areas of diminished, asymmetric, or paradoxical (two patients) CO2 reactivity appear to correspond to areas of compensatory vasodilation. We found this technique to be a safe and reproducible method for defining and recording localized areas of cerebral tissue at apparent risk for hemodynamically related damage.

Neurology

Biological and medical sciences

Vascular diseases and vascular malformations of the nervous system

Medical sciences

Details

Title: Subtitle: Cerebral perfusion reserve indexes determined by fluoromethane positron emission scanning
Creators: R. L LEVINE - William S. Middleton memorial veterans' hosp., dep. neurology, Madison WI 53705, United States
J. J SUNDERLAND - William S. Middleton memorial veterans' hosp., dep. neurology, Madison WI 53705, United States
H. L LAGREZE - William S. Middleton memorial veterans' hosp., dep. neurology, Madison WI 53705, United States
R. J NICKLES - William S. Middleton memorial veterans' hosp., dep. neurology, Madison WI 53705, United States
B. R ROWE - William S. Middleton memorial veterans' hosp., dep. neurology, Madison WI 53705, United States
P. A TURSKI - William S. Middleton memorial veterans' hosp., dep. neurology, Madison WI 53705, United States
Resource Type: Journal article
Publication Details: Stroke (1970), Vol.19(1), pp.19-27
DOI: 10.1161/01.STR.19.1.19
PMID: 3122375
NLM abbreviation: Stroke
ISSN: 0039-2499
eISSN: 1524-4628
Publisher: Lippincott Williams & Wilkins; Hagerstown, MD
Language: English
Date published: 1988
Academic Unit: Radiology; Physics and Astronomy; Radiation Oncology
Record Identifier: 9984047890602771

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