Journal article
Cerebral white matter correlates of delay discounting in adolescents
Behavioural brain research, Vol.305, pp.108-114
05/15/2016
DOI: 10.1016/j.bbr.2016.03.004
PMCID: PMC5038584
PMID: 26946275
Abstract
The adolescent brain undergoes extensive structural white matter (WM) changes. Adolescence is also a critical time period during which cognitive, emotional and social maturation occurs in transition into adulthood. Compared to adults, adolescents are generally more impulsive with increased risk-taking behaviors. The goal of this study is to examine whether adolescent impulsivity may be related to cerebral WM maturation. In 89 healthy adolescents, we assessed impulsivity using the delay discounting task, and MRI WM volumes in brain regions previously implicated in delay discounting behaviors. We found that smaller delay discounting AUC (area under the curve) was associated with larger WM volumes in orbitofrontal, dorsolateral and medial prefrontal cortices (PFC) and motor cortex. There were no significant effects of AUC on WM volumes within somatosensory brain regions. In our sample, younger age was significantly associated with greater WM volumes in orbitofrontal and dorsolateral PFC subregions. Even after accounting for age-related effects, preference for immediate rewards (or greater impulsivity) still correlated with larger WM volumes in prefrontal regions known to mediate cognitive control. Our findings lend further support to the notion that reduced brain WM maturity may limit the ability in adolescents to forgo immediate rewards leading to greater impulsivity. (C) 2016 Elsevier B.V. All rights reserved.
Details
- Title: Subtitle
- Cerebral white matter correlates of delay discounting in adolescents
- Creators
- Beng-Choon Ho - Roy J. and Lucille A. Carver College of MedicineJulie A. Koeppel - Roy J. and Lucille A. Carver College of MedicineAmy B. Barry - Roy J. and Lucille A. Carver College of Medicine
- Resource Type
- Journal article
- Publication Details
- Behavioural brain research, Vol.305, pp.108-114
- DOI
- 10.1016/j.bbr.2016.03.004
- PMID
- 26946275
- PMCID
- PMC5038584
- NLM abbreviation
- Behav Brain Res
- ISSN
- 0166-4328
- eISSN
- 1872-7549
- Publisher
- Elsevier
- Number of pages
- 7
- Grant note
- NARSAD Independent Investigator Award; NARSAD MH097751 / NIMH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) Herbert and Nancy Townsend Endowed Schizophrenia Research Fund Nellie Ball Research Trust R01MH097751 / NATIONAL INSTITUTE OF MENTAL HEALTH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) U54TR001356 / Biomedical Informatics Core, University of Iowa Institute for Clinical and Translational Science (NIH Clinical and Translational Science Award (CTSA) program) U54TR001356 / NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Advancing Translational Sciences (NCATS)
- Language
- English
- Date published
- 05/15/2016
- Academic Unit
- Psychiatry
- Record Identifier
- 9984280867302771
Metrics
9 Record Views