Journal article
Cerebrovascular Disease in Central Nervous System Infections
Seminars in neurology, Vol.31(3), pp.286-306
07/2011
DOI: 10.1055/s-0031-1287658
PMID: 21964846
Abstract
ABSTRACT
Cerebrovascular disease is a complication of a variety of infections affecting the central nervous system (CNS). Infection may cause vasculitis affecting primarily the vessels at the base of the brain in the setting of meningitis; an immune-mediated parainfectious process leading to vasospasm or thrombosis; or a hypercoagulable state in combination with endothelial dysfunction resulting from activation of inflammatory and procoagulant cascades. Although systemic signs and symptoms may be present to aid in the diagnosis, cerebral infarction secondary to infection may be indistinguishable from more typical causes of stroke. Confirmation of an infectious vasculitis may also be challenging, as brain biopsy, the gold standard for diagnosis, is rarely pursued. In many CNS infections, vascular complications portend a poor prognosis as they are often associated with devastating neurologic outcomes, including death, underscoring the importance of early recognition and appropriate therapy. In this review, we address bacterial, viral, fungal, and parasitic causes of cerebrovascular disease.
Details
- Title: Subtitle
- Cerebrovascular Disease in Central Nervous System Infections
- Creators
- Felicia C Chow - Harvard Medical School, Boston, MassachusettsChristina M Marra - Department of Neurology, University of Washington, Seattle, WashingtonTracey A Cho - Harvard Medical School, Boston, Massachusetts
- Resource Type
- Journal article
- Publication Details
- Seminars in neurology, Vol.31(3), pp.286-306
- DOI
- 10.1055/s-0031-1287658
- PMID
- 21964846
- ISSN
- 0271-8235
- eISSN
- 1098-9021
- Language
- English
- Date published
- 07/2011
- Academic Unit
- Neurology; Iowa Neuroscience Institute
- Record Identifier
- 9984070867102771
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