Cerebrovascular effects of substance P after experimental subarachnoid haemorrhage

A Pasqualin; T Tsukahara; K Hongo; O Van Beek; N F Kassell; J C Torner

doi:10.1007/BF01541798

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Cerebrovascular effects of substance P after experimental subarachnoid haemorrhage

Journal article

Peer reviewed

Cerebrovascular effects of substance P after experimental subarachnoid haemorrhage

A Pasqualin, T Tsukahara, K Hongo, O Van Beek, N F Kassell and J C Torner

Acta neurochirurgica, Vol.119(1-4), pp.139-145

1992

DOI: 10.1007/BF01541798

PMID: 1282769

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Abstract

The vasoactive effects of substance P (SP), as well as the content of cyclic guanine monophosphate (cGMP), were determined in the rabbit basilar artery after subarachnoid haemorrhage (SAH). Out of 47 rabbits, 24 were subjected to a SAH, induced by injecting 5 ml of autologous arterial blood into the cisterna magna; 23 were used as controls. In 20 animals (10 SAH and 10 controls), isometric tension recording of isolated rings of the basilar artery--dissected 2 days after SAH--was employed to assess the dose-dependent vasodilatation to SP (10(-10) to 10(-6) M) after precontraction with serotonin (10(-8) to 10(-5) M). In 15 animals (8 SAH and 7 controls), the basal cGMP content was measured in the basilar artery 2 days after SAH. In the other 12 animals (6 SAH and 6 controls), the increase in cGMP content was measured in the basilar artery after a 10-minute incubation with SP (10(-6) M). SP caused significantly less dilatation in animals subjected to SAH than in controls, especially for concentrations between 10(-9) and 10(-6) M (p < 0.001). The cGMP content in the arteries 2 days after SAH was significantly lower than in control arteries (31.5 +/- 7.3 against 57.3 +/- 4.3 pmoles/g tissue). In the preparations incubated with SP, the increase of cGMP was 440 +/- 115% in the control arteries, and only 97 +/- 30% in the arteries after SAH. It is concluded that the vasodilator activity of SP is significantly impaired after SAH.

Rabbits

Basilar Artery - drug effects

Male

Nitric Oxide - physiology

Substance P - pharmacology

Subarachnoid Hemorrhage - pathology

Vasoconstriction - drug effects

Dose-Response Relationship, Drug

Vasoconstriction - physiology

Animals

Cyclic GMP - metabolism

Basilar Artery - pathology

Vasodilation - drug effects

Vasodilation - physiology

Ischemic Attack, Transient - pathology

Details

Title: Subtitle: Cerebrovascular effects of substance P after experimental subarachnoid haemorrhage
Creators: A Pasqualin - Department of Neurological Surgery, University of Virginia Health Sciences Center, Charlottesville
T Tsukahara
K Hongo
O Van Beek
N F Kassell
J C Torner
Resource Type: Journal article
Publication Details: Acta neurochirurgica, Vol.119(1-4), pp.139-145
DOI: 10.1007/BF01541798
PMID: 1282769
NLM abbreviation: Acta Neurochir (Wien)
ISSN: 0001-6268
eISSN: 0942-0940
Publisher: Austria
Language: English
Date published: 1992
Academic Unit: Epidemiology; Surgery; Injury Prevention Research Center; Neurosurgery
Record Identifier: 9983995020402771

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