Journal article
Cerebrovascular manifestations in neurosarcoidosis: how common are they and does perivascular enhancement matter?
Clinical radiology, Vol.73(10), pp.907.e15-907.e23
10/2018
DOI: 10.1016/j.crad.2018.05.018
PMID: 29970245
Abstract
To determine the occurrence of ischaemic and haemorrhagic events in patients with neurosarcoidosis at presentation and follow-up and to evaluate its association with perivascular enhancement.
The MRI findings in patients with neurosarcoidosis who presented to our institute from 2002-2017 were retrospectively reviewed, with emphasis on cerebrovascular events. A chi-squared test was used to evaluate the statistical association with presence of perivascular enhancement.
A total of 49 patients (32 females and 17 males) were analysed. Ischaemic events were noted in four patients at presentation while parenchymal haemorrhages occurred in three patients. The combined occurrence of cerebrovascular events (CVEs) at presentation was 14%. On follow-up, three additional patients developed ischaemic infarcts, of which, one patient had parenchymal haemorrhage at presentation. Additionally, one patient also developed new parenchymal haemorrhages. In total, 10 patients in current cohort developed CVEs, either at presentation or on follow-up. Perivascular enhancement was seen in 50% of patients with cerebrovascular events and 18% of patients with neurosarcoidosis, but no CVEs. This was statistically significant (p<0.05).
CVEs in patients with neurosarcoidosis are more common than previously reported and appear to be significantly related to the presence of perivascular enhancement on imaging.
Details
- Title: Subtitle
- Cerebrovascular manifestations in neurosarcoidosis: how common are they and does perivascular enhancement matter?
- Creators
- G Bathla - Division of Neuroradiology, Department of Radiology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA. Electronic address: girish-bathla@uiowa.eduP Watal - Division of Neuroradiology, Department of Radiology, University of Iowa Hospitals and Clinics, Iowa City, IA, USAS Gupta - Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City, IA, USAN Soni - Division of Neuroradiology, Department of Radiology, University of Iowa Hospitals and Clinics, Iowa City, IA, USAA A Capizzano - Division of Neuroradiology, Department of Radiology, University of Iowa Hospitals and Clinics, Iowa City, IA, USAC P Derdeyn - Division of Neuroradiology, Department of Radiology, University of Iowa Hospitals and Clinics, Iowa City, IA, USAT Moritani - Division of Neuroradiology, Michigan Radiology, University of Michigan, Ann Arbor, MI, USA
- Resource Type
- Journal article
- Publication Details
- Clinical radiology, Vol.73(10), pp.907.e15-907.e23
- Publisher
- England
- DOI
- 10.1016/j.crad.2018.05.018
- PMID
- 29970245
- ISSN
- 0009-9260
- eISSN
- 1365-229X
- Language
- English
- Date published
- 10/2018
- Academic Unit
- Neurology; Radiology; Pathology; Iowa Neuroscience Institute; Neurosurgery
- Record Identifier
- 9984020605502771
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