Journal article
Cervical Lymph Node Metastasis Model of Pyriform Sinus Carcinoma
ORL-JOURNAL FOR OTO-RHINO-LARYNGOLOGY AND ITS RELATED SPECIALTIES, Vol.71(3), pp.129-134
01/01/2009
DOI: 10.1159/000209313
PMID: 19321975
Abstract
Objective: To establish a cervical lymph node metastasis model of pyriform sinus VX2 carcinoma and investigate its metastatic features. Methods: VX2 tumor tissue suspension was transplanted into the pyriform sinus submucosa of 15 rabbits under direct laryngoscopy. Rabbits were randomly placed into 1 of 3 groups, each comprised of 5 rabbits. Health evaluation and histopathological analysis were performed on days 14 (group 1), 21 (group 2), and 28 (group 3) after transplantation. Results: VX2 tumors were transplanted successfully in all rabbits. Dysphagia, weight loss, , and dyspnea were observed 28 days after transplantation. Deep cervical lymph node metastasis occurred in all rabbits at all time points. The rate of submandibular lymph node metastasis was 60% in group 1, 80% in group 2, and 100% in group 3. The rate of paratracheal lymph node metastasis was 0% in group 1, 80% in group 2, and 100% in group 3. Conclusions: A model of metastatic pyriform sinus carcinoma was established. This model could be used in future studies evaluating diagnostic and treatment methods. Copyright (C) 2009 S. Karger AG, Basel
Details
- Title: Subtitle
- Cervical Lymph Node Metastasis Model of Pyriform Sinus Carcinoma
- Creators
- Na Shen - Zhongshan HospitalHaitao Wu - Fudan UniversityXiuyin Xu - Fudan UniversityJianzhong Wang - Fudan UniversityMatthew R. Hoffman - Univ Wisconsin, Dept Surg, Div Otolaryngol Head & Neck Surg, Madison, WI USAAdam L. Rieves - Department of Emergency MedicineLiang Zhou - Fudan University
- Resource Type
- Journal article
- Publication Details
- ORL-JOURNAL FOR OTO-RHINO-LARYNGOLOGY AND ITS RELATED SPECIALTIES, Vol.71(3), pp.129-134
- Publisher
- Karger
- DOI
- 10.1159/000209313
- PMID
- 19321975
- ISSN
- 0301-1569
- eISSN
- 1423-0275
- Number of pages
- 6
- Language
- English
- Date published
- 01/01/2009
- Academic Unit
- Otolaryngology
- Record Identifier
- 9984366281802771
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