Journal article
Cervical Surgery for Cervical Intraepithelial Neoplasia and Prolonged Time to Conception of a Live Birth: A Case-Control Study
BJOG : an international journal of obstetrics and gynaecology, Vol.120(8), pp.960-965
03/14/2013
DOI: 10.1111/1471-0528.12209
PMCID: PMC3691952
PMID: 23489374
Abstract
Objective: To determine whether women with a history of surgery for cervical intraepithelial neoplasia (CIN) are at an increased risk of subfertility, measured as a time to pregnancy of more than 12 months.
Design: Case-control study.
Setting: Iowa Health in Pregnancy Study (IHIPS), a population-based case-control study of preterm and small-for-gestational-age (SGA) live birth outcomes (from May 2002 through June 2005) in the USA.
Sample: Women with an intended pregnancy and a history of either one prior cervical surgery (n = 152), colposcopy only (n = 151), or no prior cervical surgery or colposcopy (n = 1021).
Methods: Cervical treatment history, pregnancy intention, time to pregnancy, and other variables were self-reported by computer-assisted telephone interviews. Odds ratios were calculated using logistic regression to estimate the risk of prolonged time to pregnancy among women with a history of cervical surgery or colposcopy alone, compared with untreated women (control group).
Main outcome measure: Prolonged time to pregnancy (i.e. >1 year).
Results: Prolonged time to pregnancy was most prevalent among treated women (16.4%), compared with untreated women (8.4%) and women with colposcopy only (8.6%) (P = 0.039). After adjusting for covariates, women with prior cervical surgery had a more than two-fold higher risk of prolonged time to pregnancy compared with untreated women (aOR 2.09, 95% CI 1.26-3.46). In contrast, women with a history of colposcopy only had a risk equivalent to that found among untreated women (aOR 1.02, 95% CI 0.56-1.89).
Conclusions: Women with a history of cervical treatment for CIN are at increased risk of subfertility, measured as a time to pregnancy of more than 12 months.
Details
- Title: Subtitle
- Cervical Surgery for Cervical Intraepithelial Neoplasia and Prolonged Time to Conception of a Live Birth: A Case-Control Study
- Creators
- Cassandra N. Spracklen - University of IowaKarisa K. Harland - University of IowaBarbara J. Stegmann - University of IowaAudrey F. Saftlas - University of Iowa
- Resource Type
- Journal article
- Publication Details
- BJOG : an international journal of obstetrics and gynaecology, Vol.120(8), pp.960-965
- DOI
- 10.1111/1471-0528.12209
- PMID
- 23489374
- PMCID
- PMC3691952
- NLM abbreviation
- BJOG
- ISSN
- 1470-0328
- eISSN
- 1471-0528
- Language
- English
- Date published
- 03/14/2013
- Academic Unit
- Epidemiology; Emergency Medicine; Injury Prevention Research Center; Law Faculty
- Record Identifier
- 9984297141502771
Metrics
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