Journal article
Cervical carotid and circle of willis arterial anatomy of macaque monkeys: a comparative anatomy study
Anatomical record (Hoboken, N.J. : 2007), Vol.292(7), pp.976-984
07/2009
DOI: 10.1002/ar.20891
PMCID: PMC2743742
PMID: 19434671
Abstract
Macaque monkeys are used in many research applications, including cerebrovascular investigations. However, detailed catalogs of the relevant vascular anatomy are scarce. We present our experience with macaque vessel patterns as determined by digital subtraction angiography of 34 different monkeys. We retrospectively analyzed digital subtraction angiograms obtained during experimental internal carotid artery (ICA) catheterization and subsequent injection of 1-methyl 4-phenyl 1,2,3,6-tetrahydropyridine. Results were catalogued according to vascular distribution and variants observed. Macaque monkeys have a bovine aortic arch. The carotid vessels generally bifurcate, but are occasionally observed to divide into three vessels. The external carotid gives rise primarily to two trunks: an occipital branch and a common vessel that subsequently gives off the lingual, facial, and superior thyroid arteries. The internal maxillary artery may be present as a terminal branch of the external carotid or as a branch of the occipital artery. The ICA is similar in course to that of the human. The anterior circle of Willis was intact in all monkeys in our study. Its primary difference from that of the human is the union of the bilateral anterior cerebral arteries as a single (azygous) median vessel. Macaque cervical carotid and circle of Willis arterial anatomy differs from humans in a couple of specific patterns. Knowledge of these differences and similarities between human and macaque anatomy is important in developing endovascular macaque models of human diseases, such as ischemic stroke.
Details
- Title: Subtitle
- Cervical carotid and circle of willis arterial anatomy of macaque monkeys: a comparative anatomy study
- Creators
- Nishant Kumar - Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri 63110, USAJohn J LeeJoel S PerlmutterColin P Derdeyn
- Resource Type
- Journal article
- Publication Details
- Anatomical record (Hoboken, N.J. : 2007), Vol.292(7), pp.976-984
- Publisher
- United States
- DOI
- 10.1002/ar.20891
- PMID
- 19434671
- PMCID
- PMC2743742
- ISSN
- 1932-8486
- eISSN
- 1932-8494
- Grant note
- P50 NS055977 / NINDS NIH HHS R01 NS051631-04 / NINDS NIH HHS R01 NS039821-05 / NINDS NIH HHS R01 NS041509-07 / NINDS NIH HHS NS058714 / NINDS NIH HHS R01 NS058714 / NINDS NIH HHS R01 NS041509 / NINDS NIH HHS NS39821 / NINDS NIH HHS R01 NS050425 / NINDS NIH HHS P50 NS055977-01A2 / NINDS NIH HHS R01 NS058714-02 / NINDS NIH HHS R01 NS039821 / NINDS NIH HHS R01 NS050425-05 / NINDS NIH HHS NS41509 / NINDS NIH HHS R01 NS051631 / NINDS NIH HHS
- Language
- English
- Date published
- 07/2009
- Academic Unit
- Neurology; Radiology; Iowa Neuroscience Institute; Neurosurgery
- Record Identifier
- 9984020505702771
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