Cervical cytokine network patterns during pregnancy: the role of bacterial vaginosis and geographic ancestry

Kelli K Ryckman; Hyagriv N Simhan; Marijane A Krohn; Scott M Williams

doi:10.1016/j.jri.2008.11.003

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Cervical cytokine network patterns during pregnancy: the role of bacterial vaginosis and geographic ancestry

Journal article

Peer reviewed

Cervical cytokine network patterns during pregnancy: the role of bacterial vaginosis and geographic ancestry

Kelli K Ryckman, Hyagriv N Simhan, Marijane A Krohn and Scott M Williams

Journal of reproductive immunology, Vol.79(2), pp.174-182

2009

DOI: 10.1016/j.jri.2008.11.003

PMCID: PMC2688465

PMID: 19250684

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https://www.ncbi.nlm.nih.gov/pmc/articles/2688465View

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Abstract

Few studies have examined the coordinated regulation of the extensive network of cytokines, chemokines, and growth factors involved in the immune response to bacterial vaginosis (BV) during pregnancy. We compared these patterns between women with (BV +) and without (BV −) bacterial vaginosis and between women of African and of European ancestry. This cohort included 83 Whites (28 BV + and 55 BV −) and 80 Blacks (41 BV + and 39 BV −). Pairwise correlations were determined for 28 factors that included cytokines, chemokines, and growth factors. In Whites, there were significantly more correlations involving immunoregulatory cytokines in BV − compared with BV + women. In Blacks, there were no significant differences in the correlation patterns between BV + and BV − women. Overall, in BV − women, there were no significant differences in the correlation patterns between Whites and Blacks. Conversely, in BV + women, Blacks have a stronger correlated response to infection than Whites. This indicates that Whites and Blacks have different correlated immune responses to BV that may at least partially explain the disparity observed in the prevalence of this disease.

Bacterial vaginosis

Correlation patterns

Inflammatory response

Details

Title: Subtitle: Cervical cytokine network patterns during pregnancy: the role of bacterial vaginosis and geographic ancestry
Creators: Kelli K Ryckman - Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA
Hyagriv N Simhan - Department of Obstetrics, Gynecology, and Reproductive Sciences, Division of Maternal-Fetal Medicine and Reproductive Infectious Diseases and Immunology, University of Pittsburgh School of Medicine, Magee-Women's Research Institute, Pittsburgh, PA, USA
Marijane A Krohn - Department of Obstetrics, Gynecology, and Reproductive Sciences, Division of Maternal-Fetal Medicine and Reproductive Infectious Diseases and Immunology, University of Pittsburgh School of Medicine, Magee-Women's Research Institute, Pittsburgh, PA, USA
Scott M Williams - Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA
Resource Type: Journal article
Publication Details: Journal of reproductive immunology, Vol.79(2), pp.174-182
DOI: 10.1016/j.jri.2008.11.003
PMID: 19250684
PMCID: PMC2688465
NLM abbreviation: J Reprod Immunol
ISSN: 0165-0378
eISSN: 1872-7603
Publisher: Elsevier Ireland Ltd
Language: English
Date published: 2009
Academic Unit: Stead Family Department of Pediatrics; Epidemiology
Record Identifier: 9984214835002771

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