Journal article
Chagas Disease Screening Using Point-of-Care Testing in an At-Risk Obstetric Population
The American journal of tropical medicine and hygiene, Vol.104(3), pp.959-963
03/01/2021
DOI: 10.4269/ajtmh.20-0517
PMCID: 7941822
PMID: 33350375
Abstract
Congenital transmission is the most important mode of transmission of Chagas disease (CD) in nonendemic countries. Identifying CD in reproductive-aged women is essential to reduce the risk of transmitting the disease to their children and offer treatment to women and their children, which could cure the disease. We evaluated the use of point-of-care (POC) testing for CD in postpartum patients. In our patient population, 16.7% (23/138) tested positive by POC testing, but confirmatory testing was negative for all patients. Among those considered high risk, 30% declined participation. Our results suggest limited utility of the point-of-care test used in our study and identify an opportunity for improvement to broaden diagnostic testing options. Our study also highlights the need to develop strategies to increase subject participation in future research.
Chagas disease (CD) is a parasitic disease caused by the protozoan Trypanosoma cruzi; it affects more than 5.7 million people worldwide, claims 12,000 lives annually, and causes the greatest burden of disability-adjusted life years of any parasitic disease in Latin America. Approximately 1.2 million of those affected are women of childbearing age.1,2 Chagas disease is present in rural areas in endemic countries, and due to migration of infected individuals from rural to urban areas in Latin America and international migration from endemic to non-endemic countries, CD has emerged as a public health concern in non-endemic countries, including the United States.3,4 Approximately 23 million people living in the United States were born in CD-endemic countries, and an estimated > 300,000 people living in the United States are infected
Details
- Title: Subtitle
- Chagas Disease Screening Using Point-of-Care Testing in an At-Risk Obstetric Population
- Creators
- Lindsey E. Zamora - Vanderbilt University Medical CenterFederico Palacio - University of CincinnatiDebra S. Kozlowski - Emory UniversityKamini Doraivelu - Emory UniversityCarolynn M. Dude - Emory UniversityDenise J. Jamieson - Emory UniversityLisa B. Haddad - Emory University
- Resource Type
- Journal article
- Publication Details
- The American journal of tropical medicine and hygiene, Vol.104(3), pp.959-963
- Publisher
- Amer Soc Trop Med & Hygiene
- DOI
- 10.4269/ajtmh.20-0517
- PMID
- 33350375
- PMCID
- 7941822
- ISSN
- 0002-9637
- eISSN
- 1476-1645
- Number of pages
- 5
- Grant note
- Emory Medical Care Foundation
- Language
- English
- Date published
- 03/01/2021
- Academic Unit
- Obstetrics and Gynecology; VPMA - Administration
- Record Identifier
- 9984446515702771
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