Chagas heart disease: report on recent developments

Fabiana S Machado; Linda A Jelicks; Louis V Kirchhoff; Jamshid Shirani; Fnu Nagajyothi; Shankar Mukherjee; Randin Nelson; Christina M Coyle; David C Spray; Antonio C Campos de Carvalho; Fangxia Guan; Cibele M Prado; Michael P Lisanti; Louis M Weiss; Susan P Montgomery; Herbert B Tanowitz

doi:10.1097/CRD.0b013e31823efde2

Journal article

Chagas heart disease: report on recent developments

Fabiana S Machado, Linda A Jelicks, Louis V Kirchhoff, Jamshid Shirani, Fnu Nagajyothi, Shankar Mukherjee, Randin Nelson, Christina M Coyle, David C Spray, Antonio C Campos de Carvalho, …

Cardiology in review, Vol.20(2), pp.53-65

03/2012

DOI: 10.1097/CRD.0b013e31823efde2

PMCID: PMC3275684

PMID: 22293860

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Abstract

Chagas disease, caused by the parasite Trypanosoma cruzi, is an important cause of cardiac disease in endemic areas of Latin America. It is now being diagnosed in nonendemic areas because of immigration. Typical cardiac manifestations of Chagas disease include dilated cardiomyopathy, congestive heart failure, arrhythmias, cardioembolism, and stroke. Clinical and laboratory-based research to define the pathology resulting from T. cruzi infection has shed light on many of the cellular and molecular mechanisms leading to these manifestations. Antiparasitic treatment may not be appropriate for patients with advanced cardiac disease. Clinical management of Chagas heart disease is similar to that used for cardiomyopathies caused by other processes. Cardiac transplantation has been successfully performed in a small number of patients with Chagas heart disease.

Animals

Chagas Cardiomyopathy - diagnosis

Chagas Cardiomyopathy - epidemiology

Chagas Cardiomyopathy - therapy

Defibrillators, Implantable

Disease Models, Animal

Early Diagnosis

Echocardiography

Eicosanoids - physiology

Endothelin-1 - biosynthesis

Endothelin-1 - physiology

Heart Transplantation

Humans

Life Cycle Stages

Magnetic Resonance Angiography

Mice

Pacemaker, Artificial

Rats

Stem Cell Transplantation - methods

Trypanocidal Agents - therapeutic use

Trypanosoma cruzi - growth & development

Vasoconstriction - physiology

Details

Title: Subtitle: Chagas heart disease: report on recent developments
Creators: Fabiana S Machado - Universidade Federal de Minas Gerais
Linda A Jelicks - Physiology & Biophysics
Louis V Kirchhoff - United States Department of Veterans Affairs
Jamshid Shirani - St. Luke's-Roosevelt Hospital Center
Fnu Nagajyothi
Shankar Mukherjee - Yeshiva University
Randin Nelson
Christina M Coyle
David C Spray - Neuroscience
Antonio C Campos de Carvalho
Fangxia Guan
Cibele M Prado - Universidade de São Paulo
Michael P Lisanti - Thomas Jefferson University
Louis M Weiss
Susan P Montgomery - Centers for Disease Control and Prevention
Herbert B Tanowitz - Yeshiva University
Resource Type: Journal article
Publication Details: Cardiology in review, Vol.20(2), pp.53-65
DOI: 10.1097/CRD.0b013e31823efde2
PMID: 22293860
PMCID: PMC3275684
ISSN: 1061-5377
eISSN: 1538-4683
Grant note: HL-73732 / NHLBI NIH HHS AI-076248 / NIAID NIH HHS R01 AI076248-05 / NIAID NIH HHS AI062730 / NIAID NIH HHS CA123334 / NCI NIH HHS R01 HL073732 / NHLBI NIH HHS D43 TW007129-09 / FIC NIH HHS R21 AI062730 / NIAID NIH HHS R21 CA123334 / NCI NIH HHS D43 TW007129 / FIC NIH HHS R01 AI076248 / NIAID NIH HHS
Language: English
Date published: 03/2012
Academic Unit: Psychiatry; Infectious Diseases; Epidemiology; Internal Medicine
Record Identifier: 9984280836202771

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