Challenges and opportunities for pediatric severe TBI-review of the evidence and exploring a way forward

Michael J Bell; P David Adelson; Stephen R Wisniewski; Investigators of the ADAPT Study

doi:10.1007/s00381-017-3530-y

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Challenges and opportunities for pediatric severe TBI-review of the evidence and exploring a way forward

Journal article

Peer reviewed

Challenges and opportunities for pediatric severe TBI-review of the evidence and exploring a way forward

Michael J Bell, P David Adelson, Stephen R Wisniewski and Investigators of the ADAPT Study

Child's nervous system, Vol.33(10), pp.1663-1667

10/2017

DOI: 10.1007/s00381-017-3530-y

PMID: 29149394

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Abstract

Traumatic brain injury (TBI) is a leading killer of children in the developed and developing world. Despite evidence-based guidelines and several recent clinical trials, the progress in developing best practices for children with severe TBI has been slow. This article describes (i) the burden of the disease, (ii) the inadequacies of the evidence-based guidelines, (iii) the failure of the largest clinical trials to prove their primary hypotheses, and (iv) possible advances from an observational cohort study called the Approaches and Decisions for Acute Pediatric TBI (ADAPT) Trial that has recently completed enrollment.

Comparative effectiveness research

Evidenced-based guidelines

Pediatric neurotrauma

Severe traumatic brain injury

Children

Pediatric neurocritical care

Details

Title: Subtitle: Challenges and opportunities for pediatric severe TBI-review of the evidence and exploring a way forward
Creators: Michael J Bell - Department of Pediatrics and Critical Care Medicine, Children's National Medical Center, 111 Michigan Avenue, NW, Washington, DC, 20010, USA. mbell@childrensnational.org
P David Adelson - Department of Neurological Surgery and Barrow Neurological Institute at Phoenix Children's Hospital, Phoenix, AZ, USA
Stephen R Wisniewski - Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA
Investigators of the ADAPT Study
Contributors: Elizabeth A Newell (Contributor) - University of Iowa, Stead Family Department of Pediatrics
Resource Type: Journal article
Publication Details: Child's nervous system, Vol.33(10), pp.1663-1667
Publisher: Germany
DOI: 10.1007/s00381-017-3530-y
PMID: 29149394
ISSN: 0256-7040
eISSN: 1433-0350
Grant note: NS081041 / National Institute of Neurological Disorders and Stroke
Language: English
Date published: 10/2017
Academic Unit: Critical Care; Stead Family Department of Pediatrics; Iowa Neuroscience Institute
Record Identifier: 9984070959202771

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