Challenges and opportunities in dermal/transdermal delivery

Kalpana S Paudel; Mikolaj Milewski; Courtney L Swadley; Nicole K Brogden; Priyanka Ghosh; Audra L Stinchcomb

doi:10.4155/tde.10.16

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Challenges and opportunities in dermal/transdermal delivery

Journal article

Open access

Peer reviewed

Challenges and opportunities in dermal/transdermal delivery

Kalpana S Paudel, Mikolaj Milewski, Courtney L Swadley, Nicole K Brogden, Priyanka Ghosh and Audra L Stinchcomb

Therapeutic delivery, Vol.1(1), pp.109-131

07/2010

DOI: 10.4155/tde.10.16

PMID: 21132122

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https://www.ncbi.nlm.nih.gov/pmc/articles/2995530View

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Abstract

Transdermal drug delivery is an exciting and challenging area. There are numerous transdermal delivery systems currently available on the market. However, the transdermal market still remains limited to a narrow range of drugs. Further advances in transdermal delivery depend on the ability to overcome the challenges faced regarding the permeation and skin irritation of the drug molecules. Emergence of novel techniques for skin permeation enhancement and development of methods to lessen skin irritation would widen the transdermal market for hydrophilic compounds, macromolecules and conventional drugs for new therapeutic indications. As evident from the ongoing clinical trials of a wide variety of drugs for various clinical conditions, there is a great future for transdermal delivery of drugs.

Details

Title: Subtitle: Challenges and opportunities in dermal/transdermal delivery
Creators: Kalpana S Paudel - College of Pharmacy, University of Kentucky, Lexington, KY 40536-0200, USA
Mikolaj Milewski - College of Pharmacy, University of Kentucky, Lexington, KY 40536-0200, USA
Courtney L Swadley - College of Pharmacy, University of Kentucky, Lexington, KY 40536-0200, USA
Nicole K Brogden - College of Pharmacy, University of Kentucky, Lexington, KY 40536-0200, USA
Priyanka Ghosh - College of Pharmacy, University of Kentucky, Lexington, KY 40536-0200, USA
Audra L Stinchcomb - College of Pharmacy, University of Kentucky, Lexington, KY 40536-0200, USA
Resource Type: Journal article
Publication Details: Therapeutic delivery, Vol.1(1), pp.109-131
DOI: 10.4155/tde.10.16
PMID: 21132122
NLM abbreviation: Ther Deliv
ISSN: 2041-5990
eISSN: 2041-6008
Language: English
Date published: 07/2010
Academic Unit: Dermatology; Pharmaceutical Sciences and Experimental Therapeutics
Record Identifier: 9984025683602771

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