Journal article
Challenges, highlights, and opportunities in cellular transplantation: A white paper of the current landscape
American journal of transplantation, Vol.21(10), pp.3225-3238
10/2021
DOI: 10.1111/ajt.16740
PMID: 34212485
Abstract
Although cellular transplantation remains a relatively small field compared to solid organ transplantation, the prospects for advancement in basic science and clinical care remain bountiful. In this review, notable historical events and the current landscape of the field of cellular transplantation are reviewed with an emphasis on islets (allo‐ and xeno‐), hepatocytes (including bioartificial liver), adoptive regulatory immunotherapy, and stem cells (SCs, specifically endogenous organ‐specific and mesenchymal). Also, the nascent but rapidly evolving field of three‐dimensional bioprinting is highlighted, including its major processing steps and latest achievements. To reach its full potential where cellular transplants are a more viable alternative than solid organ transplants, fundamental change in how the field is regulated and advanced is needed. Greater public and private investment in the development of cellular transplantation is required. Furthermore, consistent with the call of multiple national transplant societies for allo‐islet transplants, the oversight of cellular transplants should mirror that of solid organ transplants and not be classified under the unsustainable, outdated model that requires licensing as a drug with the Food and Drug Administration. Cellular transplantation has the potential to bring profound benefit through progress in bioengineering and regenerative medicine, limiting immunosuppression‐related toxicity, and providing markedly reduced surgical morbidity.
The authors summarize the field of cellular transplantation with an emphasis on islets, hepatocytes, adoptive regulatory immunotherapy, and stem cells, while also highlighting recent advances in three‐dimensional bioprinting and discussing the necessary steps for the field to reach its full potential as a viable alternative to solid organ transplantation.
Details
- Title: Subtitle
- Challenges, highlights, and opportunities in cellular transplantation: A white paper of the current landscape
- Creators
- Ronald F. Parsons - Emory UniversityAngeles Baquerizo - Scripps HealthVarvara A. Kirchner - University of MinnesotaSayeed Malek - Brigham and Women's HospitalChirag S. Desai - University of North Carolina at Chapel HillAustin Schenk - The Ohio State UniversityErik B. Finger - University of MinnesotaTodd V. Brennan - Cedars-Sinai Medical CenterKalpaj R. Parekh - Roy J. and Lucille A. Carver College of MedicineMalcolm MacConmara - The University of Texas Southwestern Medical CenterKenneth Brayman - University of VirginiaJeffrey Fair - The University of Texas Medical Branch at GalvestonJason A. Wertheim - University of ArizonaASTS Cellular Transplantation Committee
- Resource Type
- Journal article
- Publication Details
- American journal of transplantation, Vol.21(10), pp.3225-3238
- DOI
- 10.1111/ajt.16740
- PMID
- 34212485
- ISSN
- 1600-6135
- eISSN
- 1600-6143
- Number of pages
- 14
- Language
- English
- Date published
- 10/2021
- Academic Unit
- Anatomy and Cell Biology; Cardiothoracic Surgery
- Record Identifier
- 9984284329302771
Metrics
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