Journal article
Challenges in Nerve Repair and Reconstruction
Hand clinics, Vol.39(3), pp.403-415
08/01/2023
DOI: 10.1016/j.hcl.2023.05.001
PMID: 37453767
Abstract
Peripheral nerve injuries can substantially impair a patient's quality of life. Despite appropriate surgi-cal intervention, outcomes often remain poor and functional recovery does not occur in many cases. When possible, direct end-to-end nerve repair is the treatment of choice. The presence of signifi-cant retraction or nerve defects causing excessive tension at a repair site often precludes direct repair. Nerve autografts remain the gold standard for the reconstruction of larger nerve gaps, but donor site morbidity remains a notable challenge. Processed nerve allografts and conduits are viable options for reconstruction that avoid donor site morbidity. These two options pose their own chal-lenges, as evidence supporting their use is limited to small-diameter nerve injuries with short defects. Nerve transfers are a relatively new technique that has gained momentum over the past couple of de-cades. However, functional recovery may be limited if the degeneration of the recipient motor endplates has already occurred. Future directions include molecular and cell-based therapies and pharmacologic agents to enhance regeneration and hopefully improve the outcomes of these chal-lenging injuries.
Details
- Title: Subtitle
- Challenges in Nerve Repair and Reconstruction
- Creators
- James S. Lin - The Ohio State University Wexner Medical CenterSonu A. Jain - The Ohio State University Wexner Medical Center
- Resource Type
- Journal article
- Publication Details
- Hand clinics, Vol.39(3), pp.403-415
- DOI
- 10.1016/j.hcl.2023.05.001
- PMID
- 37453767
- ISSN
- 0749-0712
- eISSN
- 1558-1969
- Publisher
- Elsevier
- Number of pages
- 13
- Grant note
- multicenter RANGER study from Axogen, Inc
- Language
- English
- Date published
- 08/01/2023
- Academic Unit
- Orthopedics and Rehabilitation
- Record Identifier
- 9985237501502771
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