Journal article
Change in volume of lumpectomy cavity during external-beam irradiation of the intact breast
International journal of radiation oncology, biology, physics, Vol.65(4), pp.1161-1164
2006
DOI: 10.1016/j.ijrobp.2006.02.009
PMID: 16682143
Abstract
Purpose: Definition of the lumpectomy cavity is an important component of irradiation of the breast. We use computed tomography (CT)-based planning and contour the lumpectomy volume on the planning CT. We obtained a second CT in the 4th or 5th week of treatment for boost planning and compared the volume change with the first planning-CT scan.
Methods and Materials: This retrospective study reviewed the planning-CT data for 20 patients. In the first CT, images were obtained from the mandible to 2 cm below the breast in 3-mm slices. In the second CT, for the boost, images were obtained from the top to the bottom of the clinically defined breast, in 3-mm slices. Lumpectomy cavities were contoured on both CT scans and volumes compared.
Results: Sixteen of the 20 patients (80%) had more than a 20% decrease from the first to the second volume, with a corresponding 95% confidence interval. The mean decrease was 16.13 cc, with a standard deviation of 14.05. The Spearman correlation coefficient of 0.18 did not show a significant correlation between the initial volume and the percent change.
Conclusions: During external breast irradiation, many patients will have significant volume reduction in the lumpectomy cavity. Because CT-based definition of the lumpectomy cavity can influence the planning of a boost technique, further study appears warranted.
Details
- Title: Subtitle
- Change in volume of lumpectomy cavity during external-beam irradiation of the intact breast
- Creators
- Geraldine Jacobson - Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, IAVicki Betts - Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, IABrian Smith - Department of Biostatistics, University of Iowa, Iowa City, IA
- Resource Type
- Journal article
- Publication Details
- International journal of radiation oncology, biology, physics, Vol.65(4), pp.1161-1164
- DOI
- 10.1016/j.ijrobp.2006.02.009
- PMID
- 16682143
- NLM abbreviation
- Int J Radiat Oncol Biol Phys
- ISSN
- 0360-3016
- eISSN
- 1879-355X
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 2006
- Academic Unit
- Biostatistics; Holden Comprehensive Cancer Center
- Record Identifier
- 9983997471502771
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