Journal article
Changes in Dietary Intake of Methionine, Folate/Folic Acid and Vitamin B12 and Survival in Postmenopausal Women with Breast Cancer: A Prospective Cohort Study
Nutrients, Vol.14(22), p.4747
11/10/2022
DOI: 10.3390/nu14224747
PMCID: PMC9699275
PMID: 36432434
Abstract
Background: Previous experimental studies showed that limiting methionine in the diet of animals or in cell culture media suppresses mammary cancer cell proliferation or metastasis. However, no previous study has investigated the associations of changes in methionine intake with survival among breast cancer survivors. We aimed to examine the association between changes in dietary intake of methionine, folate/folic acid, and vitamin B12 from before to after diagnosis of breast cancer, and mortality among breast cancer survivors. Methods: We included 1553 postmenopausal women from the Women’s Health Initiative who were diagnosed with invasive breast cancer and completed a food frequency questionnaire both before and after breast cancer diagnosis. Multivariable Cox proportional hazards regression models were used to estimate adjusted hazard ratios (HRs) and 95% confidence (CIs) of all-cause and breast cancer mortality associated with changes in methionine intake and changes in folate/folic acid and vitamin B12 intake. Results: Relative to pre-diagnosis, 28% of women decreased methionine intake by ≥20%, 30% of women increased methionine intake by ≥20%, and 42% of women had a relatively stable methionine intake (±19.9%) following breast cancer diagnosis. During a mean 16.1 years of follow up, there were 772 deaths in total, including 195 deaths from breast cancer. Compared to women with relatively stable methionine intake, women with decreased methionine intake had lower risks of all-cause (HR 0.78, 95% CI 0.62–0.97) and breast cancer mortality (HR 0.58, 95% CI 0.37–0.91) in fully adjusted models. In contrast, increased methionine intake or changes in folate/folic acid or vitamin B12 intake were not associated with all-cause or breast cancer mortality. Conclusions: Among breast cancer survivors, decreased methionine intake after breast cancer diagnosis was associated with lower risk of all-cause and breast cancer mortality.
Details
- Title: Subtitle
- Changes in Dietary Intake of Methionine, Folate/Folic Acid and Vitamin B12 and Survival in Postmenopausal Women with Breast Cancer: A Prospective Cohort Study
- Creators
- Yangbo Sun - University of Tennessee Health Science CenterJay H. Fowke - Department of Preventive Medicine, College of Medicine, The University of Tennessee Health Science Center, 66 N. Pauline Street, Memphis, TN 38163, USA Institute of Public Health, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230026, China Department of Endocrinology, Division of Life Sciences and Medicine, First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei 230026, China Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA 52242, USA Herbert Wertheim School of Public Health and Human Longevity Science, University of California, San Diego, CA 92093, USA College of Medicine, Sulaiman AlRajhi University, Al Bukayriah 51941, Saudi Arabia College of Public Health and Health Professions, University of Florida, Gainesville, FL 32610, USAXiaoyu Liang - Department of Preventive Medicine, College of Medicine, The University of Tennessee Health Science Center, 66 N. Pauline Street, Memphis, TN 38163, USA Institute of Public Health, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230026, China Department of Endocrinology, Division of Life Sciences and Medicine, First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei 230026, China Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA 52242, USA Herbert Wertheim School of Public Health and Human Longevity Science, University of California, San Diego, CA 92093, USA College of Medicine, Sulaiman AlRajhi University, Al Bukayriah 51941, Saudi Arabia College of Public Health and Health Professions, University of Florida, Gainesville, FL 32610, USAKhyobeni Mozhui - Department of Preventive Medicine, College of Medicine, The University of Tennessee Health Science Center, 66 N. Pauline Street, Memphis, TN 38163, USA Institute of Public Health, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230026, China Department of Endocrinology, Division of Life Sciences and Medicine, First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei 230026, China Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA 52242, USA Herbert Wertheim School of Public Health and Human Longevity Science, University of California, San Diego, CA 92093, USA College of Medicine, Sulaiman AlRajhi University, Al Bukayriah 51941, Saudi Arabia College of Public Health and Health Professions, University of Florida, Gainesville, FL 32610, USASaunak Sen - Department of Preventive Medicine, College of Medicine, The University of Tennessee Health Science Center, 66 N. Pauline Street, Memphis, TN 38163, USA Institute of Public Health, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230026, China Department of Endocrinology, Division of Life Sciences and Medicine, First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei 230026, China Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA 52242, USA Herbert Wertheim School of Public Health and Human Longevity Science, University of California, San Diego, CA 92093, USA College of Medicine, Sulaiman AlRajhi University, Al Bukayriah 51941, Saudi Arabia College of Public Health and Health Professions, University of Florida, Gainesville, FL 32610, USAWei Bao - University of IowaBuyun Liu - University of IowaLinda G. Snetselaar - University of IowaRobert B. Wallace - University of IowaAladdin H. Shadyab - University of IowaNazmus Saquib - University of IowaTing-Yuan David Cheng - Department of Preventive Medicine, College of Medicine, The University of Tennessee Health Science Center, 66 N. Pauline Street, Memphis, TN 38163, USA Institute of Public Health, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230026, China Department of Endocrinology, Division of Life Sciences and Medicine, First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei 230026, China Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA 52242, USA Herbert Wertheim School of Public Health and Human Longevity Science, University of California, San Diego, CA 92093, USA College of Medicine, Sulaiman AlRajhi University, Al Bukayriah 51941, Saudi Arabia College of Public Health and Health Professions, University of Florida, Gainesville, FL 32610, USAKaren C. Johnson - University of Tennessee Health Science Center
- Resource Type
- Journal article
- Publication Details
- Nutrients, Vol.14(22), p.4747
- DOI
- 10.3390/nu14224747
- PMID
- 36432434
- PMCID
- PMC9699275
- NLM abbreviation
- Nutrients
- eISSN
- 2072-6643
- Publisher
- MDPI
- Language
- English
- Date published
- 11/10/2022
- Academic Unit
- Epidemiology; Fraternal Order of Eagles Diabetes Research Center; Injury Prevention Research Center; Internal Medicine
- Record Identifier
- 9984319358402771
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