Journal article
Changes in Joint Contact Mechanics in a Large Quadrupedal Animal Model After Partial Meniscectomy and a Focal Cartilage Injury
Journal of biomechanical engineering, Vol.139(5), pp.0545011-0545015
05/01/2017
DOI: 10.1115/1.4036148
PMCID: PMC5444013
PMID: 28267190
Abstract
Acute mechanical damage and the resulting joint contact abnormalities are central to the initiation and progression of post-traumatic osteoarthritis (PTOA). Study of PTOA is typically performed in vivo with replicate animals using artificially induced injury features. The goal of this work was to measure changes in a joint contact stress in the knee of a large quadruped after creation of a clinically realistic overload injury and a focal cartilage defect. Whole-joint overload was achieved by excising a 5-mm wedge of the anterior medial meniscus. Focal cartilage defects were created using a custom pneumatic impact gun specifically developed and mechanically characterized for this work. To evaluate the effect of these injuries on joint contact mechanics, Tekscan (Tekscan, Inc., South Boston, MA) measurements were obtained pre-operatively, postmeniscectomy, and postimpact (1.2-J) in a nonrandomized group of axially loaded cadaveric sheep knees. Postmeniscectomy, peak contact stress in the medial compartment is increased by 71% (p = 0.03) and contact area is decreased by 35% (p = 0.001); the center of pressure (CoP) shifted toward the cruciate ligaments in both the medial (p = 0.004) and lateral (p = 0.03) compartments. The creation of a cartilage defect did not significantly change any aspect of contact mechanics measured in the meniscectomized knee. This work characterizes the mechanical environment present in a quadrupedal animal knee joint after two methods to reproducibly induce joint injury features that lead to PTOA.
Details
- Title: Subtitle
- Changes in Joint Contact Mechanics in a Large Quadrupedal Animal Model After Partial Meniscectomy and a Focal Cartilage Injury
- Creators
- David J Heckelsmiller - Department of Orthopedics and Rehabilitation, The University of Iowa, Iowa City, IA 52242-1100;Department of Biomedical Engineering, The University of Iowa, Iowa City, IA 52242-1100M James Rudert - Department of Orthopedics and Rehabilitation, The University of Iowa, Iowa City, IA 52242-1100Thomas E Baer - Department of Orthopedics and Rehabilitation, The University of Iowa, Iowa City, IA 52242-1100Douglas R Pedersen - Department of Orthopedics and Rehabilitation, The University of Iowa, Iowa City, IA 52242-1100;Department of Biomedical Engineering, The University of Iowa, Iowa City, IA 52242-1100Douglas C Fredericks - Department of Orthopedics and Rehabilitation, The University of Iowa, Iowa City, IA 52242-1100Jessica E Goetz - Orthopedic Biomechanics Lab, Department of Orthopedics and Rehabilitation, The University of Iowa, 2181 Westlawn Building, Iowa City, IA 52242-1100;Department of Biomedical Engineering, The University of Iowa, Iowa City, IA 52242-1100 e-mail: jessica-goetz@uiowa.edu
- Resource Type
- Journal article
- Publication Details
- Journal of biomechanical engineering, Vol.139(5), pp.0545011-0545015
- DOI
- 10.1115/1.4036148
- PMID
- 28267190
- PMCID
- PMC5444013
- NLM abbreviation
- J Biomech Eng
- ISSN
- 0148-0731
- eISSN
- 1528-8951
- Publisher
- United States
- Grant note
- P50 AR055533 / NIAMS NIH HHS
- Language
- English
- Date published
- 05/01/2017
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Orthopedics and Rehabilitation; Craniofacial Anomalies Research Center
- Record Identifier
- 9984040352502771
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