Journal article
Changes in Loneliness, BDNF, and Biological Aging Predict Trajectories in a Blood-Based Epigenetic Measure of Cortical Aging: A Study of Older Black Americans
Genes, Vol.14(4), 842
03/31/2023
DOI: 10.3390/genes14040842
PMCID: PMC10138024
PMID: 37107599
Abstract
A recent epigenetic measure of aging has developed based on human cortex tissue. This cortical clock (CC) dramatically outperformed extant blood-based epigenetic clocks in predicting brain age and neurological degeneration. Unfortunately, measures that require brain tissue are of limited utility to investigators striving to identify everyday risk factors for dementia. The present study investigated the utility of using the CpG sites included in the CC to formulate a peripheral blood-based cortical measure of brain age (CC-Bd). To establish the utility of CC-Bd, we used growth curves with individually varying time points and longitudinal data from a sample of 694 aging African Americans. We examined whether three risk factors that have been linked to cognitive decline—loneliness, depression, and BDNFm—predicted CC-Bd after controlling for several factors, including three new-generation epigenetic clocks. Our findings showed that two clocks—DunedinPACE and PoAm—predicted CC-BD, but that increases in loneliness and BDNFm continued to be robust predictors of accelerated CC-Bd even after taking these effects into account. This suggests that CC-Bd is assessing something more than the pan-tissue epigenetic clocks but that, at least in part, brain health is also associated with the general aging of the organism.
Details
- Title: Subtitle
- Changes in Loneliness, BDNF, and Biological Aging Predict Trajectories in a Blood-Based Epigenetic Measure of Cortical Aging: A Study of Older Black Americans
- Creators
- Ronald L. Simons - University of GeorgiaMei Ling Ong - University of GeorgiaMan-Kit Lei - University of GeorgiaSteven R. H. Beach - University of GeorgiaYue Zhang - University of GeorgiaRobert Philibert - University of IowaMichelle M. Mielke - Wake Forest University
- Resource Type
- Journal article
- Publication Details
- Genes, Vol.14(4), 842
- DOI
- 10.3390/genes14040842
- PMID
- 37107599
- PMCID
- PMC10138024
- NLM abbreviation
- Genes (Basel)
- eISSN
- 2073-4425
- Publisher
- MDPI
- Grant note
- RF1 AG077386 / National Institute on Aging R01 HL118045 / National Heart, Lung, Blood Institute R01 AG055393 / National 462 Institute on Aging
- Language
- English
- Date published
- 03/31/2023
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Psychiatry; Iowa Neuroscience Institute
- Record Identifier
- 9984399639102771
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