Journal article
Changes in Lung Volumes with Spirometric Disease Progression in COPD
Chronic obstructive pulmonary diseases, Vol.10(3), pp.270-285
2023
DOI: 10.15326/jcopdf.2022.0363
PMCID: PMC10484496
PMID: 37199719
Abstract
Abnormal lung volumes representing air trapping identify the subset of smokers with preserved spirometry who develop spirometric COPD and adverse outcomes. However, how lung volumes evolve in early COPD as airflow obstruction develops remains unclear.
To establish how lung volumes change with development of spirometric COPD, we examined lung volumes from the pulmonary function data (seated posture) available in the U.S. Department of Veterans Affairs electronic health records (n=71,356) and lung volumes measured by computed tomography (supine posture) available from COPDGene (n=7,969) and SPIROMICS (n=2,552) cohorts, and studied their cross-sectional distributions and longitudinal changes across airflow obstruction spectrum. Patients with preserved ratio impaired spirometry (PRISm) were excluded from this analysis.
Lung volumes from all three cohorts showed similar patterns of distributions and longitudinal changes with worsening airflow obstruction. The distributions for total lung capacity (TLC), vital capacity (VC), and inspiratory capacity (IC) and their patterns of change were nonlinear and included different phases. When stratified by airflow obstruction using GOLD stages, patients with GOLD-1 (mild) COPD had larger lung volumes (TLC, VC, IC) compared to patients with GOLD-0 (smokers with preserved spirometry) or GOLD-2 (moderate) disease. In longitudinal follow-up of baseline GOLD-0 patients who progressed to spirometric COPD, those with initially higher TLC and VC developed mild obstruction (GOLD-1) while those with initially lower TLC and VC developed moderate obstruction (GOLD-2).
In COPD, TLC and VC have biphasic distributions, change in nonlinear fashions as obstruction worsens, and could differentiate those GOLD-0 patients at risk for more rapid spirometric disease progression.
Details
- Title: Subtitle
- Changes in Lung Volumes with Spirometric Disease Progression in COPD
- Creators
- Mehrdad Arjomandi - University of California, San FranciscoSiyang Zeng - University of WashingtonJianhong Chen - University of California, San FranciscoSurya P Bhatt - University of Alabama at BirminghamFereidoun Abtin - University of California, Los AngelesIgor Barjaktarevic - Department of Medicine, University of California, Los Angeles, California, United StatesR Graham Barr - Columbia University Irving Medical CenterEugene R Bleecker - University of ArizonaRussell G Buhr - University of California, Los AngelesGerard J Criner - Temple UniversityAlejandro P Comellas - University of IowaDavid J Couper - University of North Carolina, Chapel Hill, North Carolina, United StatesJeffrey L Curtis - University of Michigan–Ann ArborMark T Dransfield - University of Alabama at BirminghamSpyridon Fortis - University of IowaMeiLan K Han - University of North Carolina, Chapel Hill, North Carolina, United StatesNadia N Hansel - Johns Hopkins Medical Institute, Baltimore, United StatesEric A Hoffman - University of IowaJohn E Hokanson - Department of Epidemiology, School of Public Health, University of Colorado, United StatesRobert J Kaner - Weill Cornell Medical Center, New York, New York, United StatesRichard E Kanner - University of UtahJerry A Krishnan - University of Illinois at ChicagoWassim Labaki - University of North Carolina, Chapel Hill, North Carolina, United StatesDavid A Lynch - National Jewish HealthVictor E Ortega - Mayo Clinic in ArizonaStephen P Peters - Wake Forest School of Medicine, Winston-Salem, North Carolina, United StatesPrescott G Woodruff - University of California, San FranciscoChristopher B Cooper - University of California, Los AngelesRussell P Bowler - National Jewish HealthRobert Paine III - University of UtahStephen I Rennard - University of Nebraska Medical CenterDonald P Tashkin - Columbia University Irving Medical CenterCOPDGene and SPIROMICS Investigators
- Resource Type
- Journal article
- Publication Details
- Chronic obstructive pulmonary diseases, Vol.10(3), pp.270-285
- DOI
- 10.15326/jcopdf.2022.0363
- PMID
- 37199719
- PMCID
- PMC10484496
- ISSN
- 2372-952X
- eISSN
- 2372-952X
- Grant note
- CXV-00125 / VA T15LM007442 / NLM NIH HHS
- Language
- English
- Electronic publication date
- 05/16/2023
- Date published
- 2023
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Pulmonary, Critical Care, and Occupational Medicine; ICTS; Internal Medicine
- Record Identifier
- 9984413074102771
Metrics
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