Changes in Mineral Micronutrient Status During and After Pulmonary Exacerbation in Adults With Cystic Fibrosis

Moon Jeong Lee; Jessica A Alvarez; Ellen M Smith; David W Killilea; James F Chmiel; Patricia M Joseph; Ruth E Grossmann; Amit Gaggar; Thomas R Ziegler; Vin Tangpricha

doi:10.1177/0884533615589991

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Changes in Mineral Micronutrient Status During and After Pulmonary Exacerbation in Adults With Cystic Fibrosis

Journal article

Open access

Peer reviewed

Changes in Mineral Micronutrient Status During and After Pulmonary Exacerbation in Adults With Cystic Fibrosis

Moon Jeong Lee, Jessica A Alvarez, Ellen M Smith, David W Killilea, James F Chmiel, Patricia M Joseph, Ruth E Grossmann, Amit Gaggar, Thomas R Ziegler and Vin Tangpricha

Nutrition in clinical practice, Vol.30(6), pp.838-843

12/2015

DOI: 10.1177/0884533615589991

PMCID: PMC4701694

PMID: 26078287

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Abstract

Patients with cystic fibrosis (CF) may be at risk for micronutrient depletion, particularly during periods of illness and infection. The purpose of this study was to investigate serum micronutrient status over time in adults with CF initially hospitalized with a pulmonary exacerbation. This was an ancillary study of a multicenter trial investigating the role of high-dose vitamin D supplementation in 24 adults with CF (mean age, 29.6 ± 7.3 years). We measured serum concentrations of copper (Cu), iron (Fe), calcium (Ca), magnesium (Mg), potassium (K), and sulfur (S) in subjects at the beginning of a pulmonary exacerbation and again at 3 months. Serum concentrations of Cu, Fe, and Ca were significantly lower at baseline compared with 3 months following the pulmonary exacerbation (Cu: baseline, 1.5 ± 0.6 vs 3 months, 1.6 ± 0.6 µg/mL, P = .027; Fe: 0.8 ± 0.3 vs 1.3 ± 1.1 µg/mL, P = .026; Ca: 9.7 ± 0.8 vs 10.8 ± 2.0 mg/dL, P = .024). Serum concentrations of K, Mg, and S did not change over time (K: baseline, 4.9 ± 0.3 vs 3 months, 5.1 ± 0.5 mEq/L; Mg: 1.8 ± 0.2 vs 2.0 ± 0.3 mg/dL; S: 1288.6 ± 343 vs 1309.9 ± 290 µg/mL; P > .05 for all). Serum concentrations of Cu, Fe, and Ca increased significantly several months following recovery from acute pulmonary exacerbation in adults with CF. This may reflect decreased inflammation, improved food intake, and/or increased absorption following recovery.

Cystic Fibrosis - blood

Double-Blind Method

Follow-Up Studies

Cystic Fibrosis - physiopathology

Humans

Adult

Female

Male

Lung - physiopathology

Micronutrients - blood

Nutrition Assessment

Details

Title: Subtitle: Changes in Mineral Micronutrient Status During and After Pulmonary Exacerbation in Adults With Cystic Fibrosis
Creators: Moon Jeong Lee - Division of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University School of Medicine, and the Atlanta VA Medical Center, Atlanta, Georgia
Jessica A Alvarez - Division of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University School of Medicine, and the Atlanta VA Medical Center, Atlanta, Georgia Center for Clinical and Molecular Nutrition, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia
Ellen M Smith - Nutrition & Health Sciences Program, Laney Graduate School, Emory University, Atlanta, Georgia
David W Killilea - Nutrition & Metabolism Center, Children's Hospital Oakland Research Institute, Oakland, California
James F Chmiel - Department of Pediatrics, Case Western Reserve University School of Medicine and Rainbow Babies and Children's Hospital, Cleveland, Ohio
Patricia M Joseph - Division of Pulmonary, Critical Care & Sleep Medicine, Department of Internal Medicine, University of Cincinnati, Cincinnati, Ohio
Ruth E Grossmann - College of Nursing, University of Iowa, Iowa City, Iowa
Amit Gaggar - University of Alabama at Birmingham, Birmingham, Alabama
Thomas R Ziegler - Division of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University School of Medicine, and the Atlanta VA Medical Center, Atlanta, Georgia Center for Clinical and Molecular Nutrition, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia
Vin Tangpricha - Division of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University School of Medicine, and the Atlanta VA Medical Center, Atlanta, Georgia Center for Clinical and Molecular Nutrition, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia Nutrition & Health Sciences Program, Laney Graduate School, Emory University, Atlanta, Georgia vin.tangpricha@emory.edu
Resource Type: Journal article
Publication Details: Nutrition in clinical practice, Vol.30(6), pp.838-843
DOI: 10.1177/0884533615589991
PMID: 26078287
PMCID: PMC4701694
NLM abbreviation: Nutr Clin Pract
ISSN: 0884-5336
eISSN: 1941-2452
Publisher: United States
Grant note: K01 GM109309 / NIGMS NIH HHS P30 DK072482 / NIDDK NIH HHS UL1 TR000454 / NCATS NIH HHS T32 DK007734 / NIDDK NIH HHS K01 DK102851 / NIDDK NIH HHS K24 DK096574 / NIDDK NIH HHS
Language: English
Date published: 12/2015
Academic Unit: Orthopedics and Rehabilitation; Nursing
Record Identifier: 9984064272402771

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