Journal article
Changes in Plasma Atrial and Brain Natriuretic Peptide Levels in Children Undergoing Surgical Isolated Atrial Septal Defect Closure
Pediatric cardiology, Vol.36(6), pp.1219-1224
08/01/2015
DOI: 10.1007/s00246-015-1148-y
PMID: 25773581
Abstract
Plasma atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) levels increase after cardiopulmonary bypass (CPB) in pediatric patients. However, the exact reason for the postoperative increase remains unclear. This study elucidated the perioperative changes in plasma natriuretic peptide levels in children undergoing surgical isolated atrial septal defect (ASD) closure. Between 2010 and 2012, 24 pediatric patients (median 7.1, range 2.7-15.7 years) underwent surgery for simple ASD using CPB under ventricular fibrillation (Group A, 16 patients) or under cardiac arrest (Group B, 8 patients). Natriuretic peptide levels were measured before surgery, on postoperative day 0, 1, 3, and at the first outpatient visit. The pulmonary to systemic blood flow ratio (Qp/Qs) was estimated by echocardiography using an index of right ventricle end-diastolic area. Preoperative natriuretic peptide levels positively correlated with the Qp/Qs. Plasma ANP levels peaked on postoperative day 0, and its values were higher in Group A than in Group B patients (p < 0.001). Plasma BNP levels increased significantly in both Groups on postoperative day 1, and its values were significantly greater in Group A than in Group B patients (p = 0.007). There was a weak negative correlation between the amount of postoperative increase in natriuretic peptide levels and the Qp/Qs. There was no appreciable difference in the acute postoperative clinical course and echocardiographic parameter on postoperative day 3 between Group A and B patients. In conclusion, acute postoperative natriuretic peptide levels after isolated ASD closure were multifactorial, and they might be unreliable for predicting clinical outcomes.
Details
- Title: Subtitle
- Changes in Plasma Atrial and Brain Natriuretic Peptide Levels in Children Undergoing Surgical Isolated Atrial Septal Defect Closure
- Creators
- Yuki Nakamura - Chiba Children Hosp, Div Cardiovasc Surg, Midori, Chiba 2660007, JapanIkuo Hagino - Chiba Children Hosp, Div Cardiovasc Surg, Midori, Chiba 2660007, JapanMitsuru Aoki - Chiba Children Hosp, Div Cardiovasc Surg, Midori, Chiba 2660007, JapanKouji Higashi - Chiba Children Hosp, Div Pediat Cardiol, Midori, Chiba 2660007, JapanHiromichi Nakajima - Chiba Children Hosp, Div Pediat Cardiol, Midori, Chiba 2660007, Japan
- Resource Type
- Journal article
- Publication Details
- Pediatric cardiology, Vol.36(6), pp.1219-1224
- DOI
- 10.1007/s00246-015-1148-y
- PMID
- 25773581
- ISSN
- 0172-0643
- eISSN
- 1432-1971
- Publisher
- Springer Nature
- Number of pages
- 6
- Language
- English
- Date published
- 08/01/2015
- Academic Unit
- Cardiothoracic Surgery
- Record Identifier
- 9985163943902771
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