Journal article
Changes in Soluble Transferrin Receptor and Hemoglobin Concentrations in Malawian Mothers Are Associated with Those Values in their Exclusively Breastfed, HIV-Exposed Infants
The Journal of nutrition, Vol.144(3), pp.367-374
03/01/2014
DOI: 10.3945/jn.113.177915
PMCID: 3927549
PMID: 24381222
Abstract
Infant iron status at birth is influenced by maternal iron status during pregnancy; however, there are limited data on the extent to which maternal iron status is associated with infant iron status during exclusive breastfeeding. We evaluated how maternal and infant hemoglobin and iron status [soluble transferrin receptors (TfR) and ferritin] were related during exclusive breastfeeding in HIV-infected women and their infants. The Breastfeeding, Antiretrovirals, and Nutrition Study was a randomized controlled trial in Lilongwe, Malawi, in which HIV-infected women were assigned with a 2 X 3 factorial design to a lipid-based nutrient supplement (LNS), or no LNS, and maternal, infant, or no antiretroviral drug, and followed for 24 wk. Longitudinal models were used to relate postpartum maternal hemoglobin (n = 1926) to concurrently measured infant hemoglobin, adjusting for initial infant hemoglobin values. In a subsample, change in infant iron status (hemoglobin, log ferritin, log TfR) between 2 (n = 352) or 6 wk (n = 167) and 24 wk (n = 519) was regressed on corresponding change in the maternal indicator, adjusting for 2 or 6 wk values. A1 g/L higher maternal hemoglobin at 12, 18, and 24 wk was associated with a 0.06 g/L (P = 0.01), 0.10 g/L (P < 0.001), and 0.06 g/L (P = 0.01), respectively, higher infant hemoglobin. In the subsample, a reduction in maternal log TfR and an increase in hemoglobin from initial measurement to 24 wk were associated with the same pattern in infant values (log TfR beta = -0.18 mg/L, P < 0.001; hemoglobin beta = 0.13 g/L, P= 0.01). Given the observed influence of maternal and initial infant values, optimizing maternal iron status in pregnancy and postpartum is important to protect infant iron status. This trial was registered at clinicaltrials.gov as NCT00164736.
Details
- Title: Subtitle
- Changes in Soluble Transferrin Receptor and Hemoglobin Concentrations in Malawian Mothers Are Associated with Those Values in their Exclusively Breastfed, HIV-Exposed Infants
- Creators
- Elizabeth M. Widen - Columbia UniversityMargaret E. Bentley - University of North Carolina at Chapel HillDumbani Kayira - UNC Project, Lilongwe, MalawiCharles S. Chasela - University of the WitwatersrandEric J. Daza - University of North Carolina at Chapel HillZebrone K. Kacheche - UNC Project, Lilongwe, MalawiGerald Tegha - UNC Project, Lilongwe, MalawiDenise J. Jamieson - CDC FoundationAthena P. Kourtis - CDC FoundationCharles M. van der Horst - University of North Carolina at Chapel HillLindsay H. Allen - Western Human Nutrition Research CenterSetareh Shahab-Ferdows - Western Human Nutrition Research CenterLinda S. Adair - University of North Carolina at Chapel HillBreastfeeding, Antiretrovirals and Nutrition (BAN) Study Team
- Resource Type
- Journal article
- Publication Details
- The Journal of nutrition, Vol.144(3), pp.367-374
- Publisher
- AMER SOC NUTRITION-ASN
- DOI
- 10.3945/jn.113.177915
- PMID
- 24381222
- PMCID
- 3927549
- ISSN
- 0022-3166
- eISSN
- 1541-6100
- Number of pages
- 8
- Grant note
- Elizabeth Glaser Pediatric AIDS Foundation R24 HD050924 / Carolina Population Center P30-AI50410 / University of North Carolina Center for AIDS Research World Food Program OPP53107 / Bill and Melinda Gates Foundation; Bill & Melinda Gates Foundation SIP 13-01 U48-CCU409660-09; SIP 26-04 U48-DP000059-01; SIP 22-09 U48-DP001944-01 / Prevention Research Centers Special Interest Project of the CDC National Institute of Allergy and Infectious Diseases; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID) U.S Agency for International Development; United States Agency for International Development (USAID) Malawi Ministry of Health and Population United Nations Children's Fund Johnson and Johnson; Johnson & Johnson; Johnson & Johnson USA DHHS/NIH/FIC 2-D43 Tw01039-06; R24 Tw00798 / National Institutes of Health Fogarty AIDS International Training and Research Program
- Language
- English
- Date published
- 03/01/2014
- Academic Unit
- Obstetrics and Gynecology; VPMA - Administration
- Record Identifier
- 9984446513902771
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