Changes in antimüllerian hormone levels in early pregnancy are associated with preterm birth

Barbara J Stegmann; Mark Santillan; Benjamin Leader; Elaine Smith; Donna Santillan

doi:10.1016/j.fertnstert.2015.04.044

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Changes in antimüllerian hormone levels in early pregnancy are associated with preterm birth

Journal article

Open access

Peer reviewed

Changes in antimüllerian hormone levels in early pregnancy are associated with preterm birth

Barbara J Stegmann, Mark Santillan, Benjamin Leader, Elaine Smith and Donna Santillan

Fertility and Sterility, Vol.104(2), pp.347-355.e3

08/2015

DOI: 10.1016/j.fertnstert.2015.04.044

PMCID: PMC5057574

PMID: 26074093

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Abstract

To determine the association of preterm birth with antimüllerian hormone (AMH) levels both in isolation and in combination with other markers of fetoplacental health commonly measured during integrated prenatal screening (IPS) for aneuploidy. Retrospective case-control study. Not applicable. Pregnant women in Iowa who elected to undergo IPS and who subsequently delivered in Iowa, including women giving birth at <37 weeks' gestation and controls who delivered at ≥37 weeks' gestation. None. Probability of a preterm birth. Second trimester AMH levels were not associated with preterm birth, either independently or after controlling for other markers of fetoplacental health. The AMH difference was not associated with preterm birth when modeled alone, but a statistically significant association was found after adjusting for maternal serum α-fetoprotein (MSAFP) and maternal weight change between the first and second trimesters. After stratifying the model by MSAFP level, most of the risk for preterm birth was identified in women with an MSAFP >1 multiple of the median and who had a stable or rising AMH level in early pregnancy. A lack of decline in the AMH level in early pregnancy can be used to identify women with a high probability for preterm birth, especially when MSAFP levels are >1 multiple of the median. Monitoring changes in the AMH level between the first and second trimesters of pregnancy may help identify women who would benefit from interventional therapies such as supplemental progesterone.

preterm birth

maternal serum alpha-fetoprotein (MSAFP)

ovarian biomarkers

Antimüllerian hormone (AMH)

placental biomarkers

Details

Title: Subtitle: Changes in antimüllerian hormone levels in early pregnancy are associated with preterm birth
Creators: Barbara J Stegmann - Department of Epidemiology, College of Public Health, Iowa City, Iowa
Mark Santillan - Department of Obstetrics and Gynecology, University of Iowa Hospitals and Clinics, University of Iowa, Iowa City, Iowa
Benjamin Leader - ReproSource, Woburn, Massachusetts
Elaine Smith - Department of Epidemiology, College of Public Health, Iowa City, Iowa
Donna Santillan - Department of Obstetrics and Gynecology, University of Iowa Hospitals and Clinics, University of Iowa, Iowa City, Iowa
Resource Type: Journal article
Publication Details: Fertility and Sterility, Vol.104(2), pp.347-355.e3
DOI: 10.1016/j.fertnstert.2015.04.044
PMID: 26074093
PMCID: PMC5057574
NLM abbreviation: Fertil Steril
ISSN: 0015-0282
eISSN: 1556-5653
Publisher: Elsevier Inc
Grant note: KL2 TR000444 / National Institutes of Health (http://dx.doi.org/10.13039/100000002)
Language: English
Date published: 08/2015
Academic Unit: Epidemiology; Obstetrics and Gynecology
Record Identifier: 9983931105202771

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