Journal article
Changes in body water compartments with diuretic therapy in infants with chronic lung disease
Early human development, Vol.48(1), pp.99-107
1997
DOI: 10.1016/S0378-3782(96)01841-5
PMID: 9131311
Abstract
The effects of diuretic therapy on body water compartments were studied in preterm infants with chronic lung disease. Gestational age of the infants ranged from 24 to 28 weeks, while the median postnatal age at the time of study was 40 days. Infants were randomized to receive furosemide (1.0 mg/kg/day) alone (
n=5) or combined with metolazone (0.2 mg/kg/day,
n=7) for 4 consecutive days. Treatment in both groups produced a significant decrease (
P<0.05) in extracellular water (ECW) without changes in plasma volume, total body water or body weight. The decrease in ECW with furosemide (503±28 to 446±19 ml/kg initial body weight) was of similar magnitude to that seen with combined furosemide plus metolazone (522±30 to 454±15 ml/kg initial body weight). Water and electrolyte intakes were similar in both groups and unchanged over the course of the study. These findings suggest that in infants with chronic lung disease, diuretic therapy induces intercompartmental shifts in body water, ultimately decreasing interstitial water while preserving PV. Only combined treatment with furosemide plus metolazone produced a significant increase in urine output, confirming the increased efficacy of combination therapy in inducing diuresis.
Details
- Title: Subtitle
- Changes in body water compartments with diuretic therapy in infants with chronic lung disease
- Creators
- Jeffrey L Segar - University of IowaSylvain Chemtob - Department of Pediatrics, Hôpital Ste. Justine, Montreal, CanadaEdward F Bell - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Early human development, Vol.48(1), pp.99-107
- Publisher
- Elsevier Ireland Ltd
- DOI
- 10.1016/S0378-3782(96)01841-5
- PMID
- 9131311
- ISSN
- 0378-3782
- eISSN
- 1872-6232
- Language
- English
- Date published
- 1997
- Academic Unit
- Stead Family Department of Pediatrics; Neonatology
- Record Identifier
- 9984354151502771
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