Journal article
Changes in dimethylaniline N-oxidase activity of mouse liver and kidney induced by steroid sex hormones
Molecular pharmacology, Vol.19(1), pp.134-139
01/01/1981
DOI: 10.1016/S0026-895X(25)12522-4
PMID: 7207457
Abstract
Activity of the flavin-containing monooxygenase (EC 1.14.13.8, N,N-dimethylaniline N-oxidizing) was measured in liver, kidney, and lung homogenates obtained from control; gonadectomized; and testosterone-, β-estradiol-, and progesterone-pretreated CF-1 mice. The sex-related differences in liver microsomal N-oxidase activity described by Wirth and Thorgeirsson [Biochem. Pharmacol. 27:601-603 (1978)] appeared to be due primarily to testosterone repression of the liver enzyme. Activity, low in the adult male, rose significantly upon castration but returned to control levels upon testosterone replacement therapy. Activity of female liver, only marginally affected by ovariectomy, was markedly depressed by testosterone but rose slightly upon progesterone administration. In contrast to liver, testosterone appears to increase the amount of monooxygenase in kidney. Activity in this organ in sexually intact males was depressed by castration or by estradiol administration. The total amount of enzyme also increased following testosterone administration to gonadectomized or sexually intact females. Sex-related differences in lung N-oxidase activities could not be detected, and activity in this organ was not affected by gonadectomy or hormone pretreatment.
Details
- Title: Subtitle
- Changes in dimethylaniline N-oxidase activity of mouse liver and kidney induced by steroid sex hormones
- Creators
- Michael W DuffelJ Michael GrahamD M Ziegler
- Resource Type
- Journal article
- Publication Details
- Molecular pharmacology, Vol.19(1), pp.134-139
- DOI
- 10.1016/S0026-895X(25)12522-4
- PMID
- 7207457
- ISSN
- 0026-895X
- eISSN
- 1521-0111
- Language
- English
- Date published
- 01/01/1981
- Academic Unit
- Pharmaceutical Sciences and Experimental Therapeutics; Medicinal and Natural Products Chemistry
- Record Identifier
- 9984303163302771
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