Changes in dynamic and kinematic properties of saccades in ocular myasthenia following intravenous immunoglobulin treatment

Alessandro Serra; Matthew J Thurtell; R John Leigh

doi:10.1111/j.1749-6632.2008.03712.x

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Changes in dynamic and kinematic properties of saccades in ocular myasthenia following intravenous immunoglobulin treatment

Journal article

Peer reviewed

Changes in dynamic and kinematic properties of saccades in ocular myasthenia following intravenous immunoglobulin treatment

Alessandro Serra, Matthew J Thurtell and R John Leigh

Annals of the New York Academy of Sciences, Vol.1164(1), pp.468-471

05/2009

DOI: 10.1111/j.1749-6632.2008.03712.x

PMCID: PMC3166887

PMID: 19645950

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Abstract

The dynamics and kinematics of saccades in a patient with severe ocular myasthenia were studied before and after treatment with intravenous immunoglobulin (IVIG). Before therapy, horizontal saccades were hypometric, but faster than similar-sized saccades made by normal subjects. During a 5-minute test period, saccades decreased in size (fatigue effect), but remained faster than those of controls. Listing's plane of the eye with greater ophthalmoplegia was increased in thickness. After IVIG treatment, the range of eye movements improved, but saccades remained faster than those of controls. Also, no fatigue was observed and the thickness of Listing's plane was reduced toward the normal range. Increased peak velocity, despite progressive hypometria due to fatigue, supports the hypothesis that the pale global extraocular muscle fibers are relatively spared in myasthenia. Involvement of other extraocular muscle-fiber types leads to limited range of eye movements and an increase in the thickness of Listing's plane.

Saccades

Biomechanical Phenomena

Immunoglobulins, Intravenous - therapeutic use

Myasthenia Gravis - physiopathology

Humans

Middle Aged

Myasthenia Gravis - therapy

Male

Treatment Outcome

Details

Title: Subtitle: Changes in dynamic and kinematic properties of saccades in ocular myasthenia following intravenous immunoglobulin treatment
Creators: Alessandro Serra - The Daroff-Dell'Osso Ocular Motility Laboratory, Veterans Affairs Medical Center and Case Western Reserve University, Cleveland, Ohio, USA
Matthew J Thurtell
R John Leigh
Resource Type: Journal article
Publication Details: Annals of the New York Academy of Sciences, Vol.1164(1), pp.468-471
DOI: 10.1111/j.1749-6632.2008.03712.x
PMID: 19645950
PMCID: PMC3166887
NLM abbreviation: Ann N Y Acad Sci
ISSN: 0077-8923
eISSN: 1749-6632
Publisher: United States
Grant note: R01 EY006717-23 / NEI NIH HHS R01 EY006717 / NEI NIH HHS EY06717 / NEI NIH HHS
Language: English
Date published: 05/2009
Academic Unit: Neurology; Ophthalmology and Visual Sciences
Record Identifier: 9983980000702771

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