Journal article
Changes in histone gene dosage alter transcription in yeast
Genes & development, Vol.2(2), pp.150-159
1988
DOI: 10.1101/gad.2.2.150
PMID: 2834270
Abstract
Chromatin structure is believed to be important for a number of cellular processes, including transcription. However, the role of nucleosomes in transcription is not well understood. We have identified the yeast histone locus HTB1-HTB1, encoding histones H2A and H2B, as a suppressor of solo delta insertion mutations that inhibit adjacent gene expression. The HTA1-HTB1 locus causes suppression either when present on a high-copy-number plasmid or when mutant. These changes in HTA1-HTB1 after transcription of the genes adjacent to the delta insertions. On the basis of this result, we have examined the effects of increased and decreased histone gene dosage for all four yeast histone loci. From the types of histone gene dosage changes that cause suppression of insertion mutations, we conclude that altered stoichiometry of histone dimer sets can alter transcription in yeast.
Details
- Title: Subtitle
- Changes in histone gene dosage alter transcription in yeast
- Creators
- C. D CLARK-ADAMS - Harvard medical school. dep. genetics, Boston MA 02115, United StatesD Norris - Harvard medical school. dep. genetics, Boston MA 02115, United StatesM. A Osley - Harvard medical school. dep. genetics, Boston MA 02115, United StatesJ. S Fassler - Harvard medical school. dep. genetics, Boston MA 02115, United StatesF Winston - Harvard medical school. dep. genetics, Boston MA 02115, United States
- Resource Type
- Journal article
- Publication Details
- Genes & development, Vol.2(2), pp.150-159
- Publisher
- Cold Spring Harbor Laboratory
- DOI
- 10.1101/gad.2.2.150
- PMID
- 2834270
- ISSN
- 0890-9369
- eISSN
- 1549-5477
- Language
- English
- Date published
- 1988
- Academic Unit
- Biology
- Record Identifier
- 9984217425902771
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