Journal article
Changes in regional activity are accompanied with changes in inter-regional connectivity during 4 weeks motor learning
Brain research, Vol.1318, pp.64-76
2010
DOI: 10.1016/j.brainres.2009.12.073
PMID: 20051230
Abstract
Structural equation modeling (SEM) and fMRI were used to test whether changes in the regional activity are accompanied by changes in the inter-regional connectivity as motor practice progresses. Ten healthy subjects were trained to perform finger movement task daily for 4 weeks. Three sessions of fMRI images were acquired within 4 weeks. The changes in inter-regional connectivity were evaluated by measuring the effective connectivity between the primary motor area (M1), supplementary motor area (SMA), dorsal premotor cortex (PMd), basal ganglia (BG), cerebellum (CB), and posterior ventrolateral prefrontal cortex (pVLPFC). The regional activities in M1 and SMA increased from pre-training to week 2 and decreased from week 2 to week 4. The inter-regional connectivity generally increased in strength (with SEM path coefficients becoming more positive or negative) as practice progressed. The increases in the strength of the inter-regional connectivity may reflect long-term reorganization of the skilled motor network. We suggest that the performance gain was achieved by dynamically tuning the inter-regional connectivity in the motor network.
Details
- Title: Subtitle
- Changes in regional activity are accompanied with changes in inter-regional connectivity during 4 weeks motor learning
- Creators
- Liangsuo Ma - Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center, Houston, TX 77030, USABinquan Wang - Research Imaging Institute, University of Texas Health Science Center, San Antonio, TX 78284, USAShalini Narayana - Research Imaging Institute, University of Texas Health Science Center, San Antonio, TX 78284, USAEliot Hazeltine - Department of Psychology, University of Iowa, Iowa City, IA 52242, USAXiying Chen - Department of Radiology, University of Iowa, Iowa City, IA 52242, USADonald A Robin - Research Imaging Institute, University of Texas Health Science Center, San Antonio, TX 78284, USAPeter T Fox - Research Imaging Institute, University of Texas Health Science Center, San Antonio, TX 78284, USAJinhu Xiong - Department of Radiology, University of Iowa, Iowa City, IA 52242, USA
- Resource Type
- Journal article
- Publication Details
- Brain research, Vol.1318, pp.64-76
- Publisher
- Elsevier B.V
- DOI
- 10.1016/j.brainres.2009.12.073
- PMID
- 20051230
- ISSN
- 0006-8993
- eISSN
- 1872-6240
- Grant note
- name: National Science Foundation, award: BCS 05-09626; name: National Institute of Health, award: 5 RO1 NS046082
- Language
- English
- Date published
- 2010
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Psychological and Brain Sciences; Iowa Neuroscience Institute
- Record Identifier
- 9984070971902771
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