Changes in symptoms during urologic chronic pelvic pain syndrome symptom flares: Findings from one site of the MAPP Research Network

Siobhan Sutcliffe; Graham A Colditz; Ratna Pakpahan; Catherine S Bradley; Melody S Goodman; Gerald L Andriole; H Henry Lai

doi:10.1002/nau.22534

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Changes in symptoms during urologic chronic pelvic pain syndrome symptom flares: Findings from one site of the MAPP Research Network

Journal article

Peer reviewed

Changes in symptoms during urologic chronic pelvic pain syndrome symptom flares: Findings from one site of the MAPP Research Network

Siobhan Sutcliffe, Graham A Colditz, Ratna Pakpahan, Catherine S Bradley, Melody S Goodman, Gerald L Andriole and H Henry Lai

Neurourology and Urodynamics, Vol.34(2), pp.188-195

2015

DOI: 10.1002/nau.22534

PMCID: PMC4032370

PMID: 24273163

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Abstract

AIMS: To provide the first description and quantification of symptom changes during interstitial cystitis/bladder pain syndrome and chronic prostatitis/chronic pelvic pain syndrome symptom exacerbations ("flares").METHODS: Participants at one site of the Trans-Multidisciplinary Approaches to the study of chronic Pelvic Pain Epidemiology and Phenotyping Study completed two 10-day diaries over the 1-year study follow-up period, one at baseline and one during their first flare (if not at baseline). On each day of the diary, participants reported whether they were currently experiencing a flare, defined as "symptoms that are much worse than usual" for at least 1 day, and their levels of urination-related pain, pelvic pain, urgency, and frequency on a scale of 0-10. Linear mixed models were used to calculate mean changes in symptoms between non-flare and flare days from the same participant.RESULTS: Eighteen of 27 women and 9 of 29 men reported at least one flare during follow-up, for a total of 281 non-flare and 210 flare days. Of these participants, 44.4% reported one flare, 29.6% reported two flares, and 25.9% reported ≥ 3 flares over the combined 20-day diary observation period, with reported flares ranging in duration from 1 day to >2 weeks. During these flares, each of the main symptoms worsened significantly by a mean of at least two points and total symptoms worsened by a mean of 11 points for both sexes (all P ≤ 0.01).CONCLUSIONS: Flares are common and correspond to a global worsening of urologic and pelvic pain symptoms.

Epidemiology

flare

bladder pain syndrome

chronic pelvic pain syndrome

symptom exacerbation

chronic prostatitis

interstitial cystitis

MEN

FREQUENCY

UROLOGY & NEPHROLOGY

COHORT

BACTERIURIA

Severity of Illness Index

Cystitis, Interstitial - diagnosis

Follow-Up Studies

Humans

Middle Aged

Medical Records

Cystitis, Interstitial - physiopathology

Linear Models

Male

Prostatitis - physiopathology

Pelvic Pain - diagnosis

Disease Progression

Syndrome

Young Adult

Time Factors

Adolescent

Adult

Female

Aged

Pelvic Pain - physiopathology

Prostatitis - diagnosis

Chronic Disease

Longitudinal Studies

Medicine, Experimental

Medical research

Pelvic pain

Analysis

Article

Details

Title: Subtitle: Changes in symptoms during urologic chronic pelvic pain syndrome symptom flares: Findings from one site of the MAPP Research Network
Creators: Siobhan Sutcliffe
Graham A Colditz
Ratna Pakpahan
Catherine S Bradley - University of Iowa, Epidemiology
Melody S Goodman
Gerald L Andriole
H Henry Lai
Resource Type: Journal article
Publication Details: Neurourology and Urodynamics, Vol.34(2), pp.188-195
DOI: 10.1002/nau.22534
PMID: 24273163
PMCID: PMC4032370
NLM abbreviation: Neurourol Urodyn
ISSN: 0733-2467
eISSN: 1520-6777
Publisher: WILEY; HOBOKEN
Number of pages: 8
Grant note: NIDDK MAPP Research Network Grant, NIH (DK082315) DK082315 / National Institutes of Health U01 DK082344 / NIDDK NIH HHS DK082315 / NIDDK NIH HHS U01 DK082315 / NIDDK NIH HHS U01 DK082316 / NIDDK NIH HHS
Language: English
Date published: 2015
Description audience: Academic
Academic Unit: Epidemiology; Obstetrics and Gynecology; Urology
Record Identifier: 9983931604202771

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