Changes in the Inflammatory Potential of Diet Over Time and Risk of Colorectal Cancer in Postmenopausal Women

Fred K Tabung; Susan E Steck; Yunsheng Ma; Angela D Liese; Jiajia Zhang; Dorothy S Lane; Gloria Y F Ho; Lifang Hou; Linda Snetselaar; Judith K Ockene; James R Hebert

doi:10.1093/aje/kwx115

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Changes in the Inflammatory Potential of Diet Over Time and Risk of Colorectal Cancer in Postmenopausal Women

Journal article

Open access

Peer reviewed

Changes in the Inflammatory Potential of Diet Over Time and Risk of Colorectal Cancer in Postmenopausal Women

Fred K Tabung, Susan E Steck, Yunsheng Ma, Angela D Liese, Jiajia Zhang, Dorothy S Lane, Gloria Y F Ho, Lifang Hou, Linda Snetselaar, Judith K Ockene, …

American journal of epidemiology, Vol.186(5), pp.514-523

09/01/2017

DOI: 10.1093/aje/kwx115

PMCID: PMC5860367

PMID: 28486621

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Abstract

We examined the associations between changes in dietary inflammatory potential and risk of colorectal cancer (CRC) in 87,042 postmenopausal women recruited from 1993-1998 by the Women's Health Initiative, conducted in the United States. Food frequency questionnaire data were used to compute patterns of change in dietary inflammatory index (DII) scores and cumulative average DII scores over 3 years. Cox regression models were used to estimate hazard ratios for CRC risk. After a median of 16.2 years of follow-up, 1,038 CRC cases were diagnosed. DII changes were not substantially associated with overall CRC, but proximal colon cancer risk was higher in the proinflammatory-change DII group than in the antiinflammatory-stable DII group (hazard ratio = 1.32, 95% confidence interval: 1.01, 1.74). Among nonusers of nonsteroidal antiinflammatory drugs (NSAIDs) (Pinteraction = 0.055), the proinflammatory-stable DII group was at increased risk of overall CRC and proximal colon cancer. Also among nonusers of NSAIDs, risks of overall CRC, colon cancer, and proximal colon cancer were higher in the highest quintile compared with the lowest cumulative average DII quintile (65%, 61%, and 91% higher risk, respectively). Dietary changes toward, or a history of, proinflammatory diets are associated with an elevated risk of colon cancer, particularly for proximal colon cancer and among nonusers of NSAIDs.

Exercise

Body Mass Index

Colorectal Neoplasms - epidemiology

United States - epidemiology

Women's Health

Diet - adverse effects

Humans

Middle Aged

Risk Factors

Proportional Hazards Models

Diet Records

Feeding Behavior

Inflammation - etiology

Inflammation - complications

Colorectal Neoplasms - etiology

Anti-Inflammatory Agents, Non-Steroidal - therapeutic use

Inflammation - drug therapy

Postmenopause

Female

Aged

Longitudinal Studies

Details

Title: Subtitle: Changes in the Inflammatory Potential of Diet Over Time and Risk of Colorectal Cancer in Postmenopausal Women
Creators: Fred K Tabung
Susan E Steck
Yunsheng Ma
Angela D Liese
Jiajia Zhang - University of South Carolina
Dorothy S Lane
Gloria Y F Ho
Lifang Hou
Linda Snetselaar
Judith K Ockene
James R Hebert
Resource Type: Journal article
Publication Details: American journal of epidemiology, Vol.186(5), pp.514-523
Publisher: United States
DOI: 10.1093/aje/kwx115
PMID: 28486621
PMCID: PMC5860367
ISSN: 1476-6256
eISSN: 1476-6256
Grant note: F31 CA177255 / NCI NIH HHS
Language: English
Date published: 09/01/2017
Academic Unit: Epidemiology; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
Record Identifier: 9983995135502771

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