Journal article
Changes in whole body pain intensity and widespreadness during urologic chronic pelvic pain syndrome flares-Findings from one site of the MAPP study
Neurourology and urodynamics, Vol.38(8), pp.2333-2350
11/01/2019
DOI: 10.1002/nau.24150
PMCID: PMC9188843
PMID: 31483064
Abstract
Objective To investigate changes in whole body pain during urologic chronic pelvic pain syndrome (UCPPS) flares. Materials and Methods UCPPS participants at one site of the multidisciplinary approach to the study of chronic pelvic pain research network reported their daily flare status and pain levels in 7 pelvic/genital and 42 extrapelvic body areas (scale = 0-10) for 10 days at baseline and during their first flare. Linear mixed models and conditional logistic regression were used to investigate symptom changes during flares. Analyses were stratified by chronic overlapping pain condition (COPC) status. Results Fifty-five out of 60 participants completed the study, 27 of whom provided information on both nonflare (n = 281) and flare (n = 208) days. Pelvic/genital pain intensity (mean change = 3.20 of 10) and widespreadness (mean = 1.48) increased significantly during flares for all participants (all P interaction > .1), whereas extrapelvic pain intensity increased significantly only among participants with COPCs (mean = 2.09; P interaction < .0001). Pelvic/genital and extrapelvic pain also varied on nonflare days but symptom fluctuations were generally <= 1 point (80.0%-100% of participants). Increases of >= 2 points in pelvic/genital pain intensity (odds ratio (OR) = 22.0, 95% confidence interval (CI) = 4.0-118.6) and >= 1 point in urination-related pain (OR = 9.10, 95% CI = 1.74-47.7) were independently associated with flare onset for all participants. Conclusion Our observations of extrapelvic pain increases during flares for patients with COPCs and our independent associations between pelvic/genital/urination-related pain intensity and flare onset may provide insight into mechanisms underlying flare development (eg, common biologic pathways between UCPPS phenotypes and flares), flare management (eg, local vs systemic therapies by COPC status), and patient flare definitions.
Details
- Title: Subtitle
- Changes in whole body pain intensity and widespreadness during urologic chronic pelvic pain syndrome flares-Findings from one site of the MAPP study
- Creators
- Tianlin Xu - George Warren Brown School Washington University St Louis MissouriH. Henry Lai - Washington University in St. LouisRatna Pakpahan - Washington University in St. LouisJoel Vetter - Washington University in St. LouisGerald L. Andriole - Washington University in St. LouisCatherine Bradley - Roy J. and Lucille A. Carver College of MedicineBruce D. Naliboff - Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine, Oppenheimer Center for Neurobiology of Stress and Resilience University of California Los Angeles CaliforniaGraham A. Colditz - Washington University in St. LouisSiobhan Sutcliffe - Washington University in St. Louis
- Resource Type
- Journal article
- Publication Details
- Neurourology and urodynamics, Vol.38(8), pp.2333-2350
- DOI
- 10.1002/nau.24150
- PMID
- 31483064
- PMCID
- PMC9188843
- NLM abbreviation
- Neurourol Urodyn
- ISSN
- 0733-2467
- eISSN
- 1520-6777
- Publisher
- Wiley
- Number of pages
- 18
- Grant note
- U01DK082315 / NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK)
- Language
- English
- Date published
- 11/01/2019
- Academic Unit
- Epidemiology; Obstetrics and Gynecology; Urology
- Record Identifier
- 9984315749302771
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