Journal article
Changing trends and disparities in 5-year overall survival of women with invasive breast cancer in the United States, 1975-2015
American journal of cancer research, Vol.11(6), pp.3201-3211
06/15/2021
PMCID: PMC8263668
PMID: 34249455
Abstract
Relative survival is the ratio of overall survival (OS) over survival of the general population, and widely used in epidemiological studies. But it is artificially higher than OS and thus inferior to OS for cancer prognostication of individual patients. Moreover, trend-changes and disparities in OS of breast cancer are unclear while the relative survival of breast cancer has been reported on a regular basis. Therefore, we estimated trends in age-standardized 5-year OS of invasive breast cancer, using data from the Surveillance, Epidemiology, and End Results (SEER) cancer registry program and piecewise-linear regression models. Among 188,052 women with breast cancer diagnosed during 2007-2010 (SEER-18, 155,515 [79.3%] survived by year 5), the 5-year OS significantly differed by age, histology, tumor grade, tumor stage, hormone receptors, race/ethnicity, insurance status, region, rural-urban continuum and selected county-attributes. Among 469,498 women with breast cancer diagnosed during 1975-2010 (SEER-9) in the U.S., we observed an upward trend in the age-standardized 5-year OS (stage- and race/ethnicity-adjusted annual percentage change = 0.97 [95% CI, 0.76-1.18]). The 36-year trends/slopes in age-standardized 5-year OS of breast cancer differed by histology, tumor grade, stage, race/ethnicity, region and socioeconomic attributes of the patient’s residence-county, but not by those of rural-urban continuum. The 3-joinpoint model on the 36-year trend identified significant slope changes in 1983, 1987 and 2000, with the largest slope (2.5%/year) during 1983-1987. In conclusion, we here show trends in the age-standardized 5-year OS among U.S. women with breast cancer changed in diagnosis-years of 1983, 1987 and 2000, and differed by tumor characteristics and race/ethnicity. More efforts are needed to understand the trend changes and to address the OS disparities of breast cancers.
Details
- Title: Subtitle
- Changing trends and disparities in 5-year overall survival of women with invasive breast cancer in the United States, 1975-2015
- Creators
- Mu Yang - Department of Pathology, Princeton Medical Center Department of Pathology, Shanghai General Hospital, Shanghai Jiaotong UniversityXin Hu - Yale UniversityWei Bao - University of IowaXinmin Zhang - Cooper Medical School of Rowan UniversityYong Lin - Rutgers Cancer Institute of New Jersey Department of Biostatistics and Epidemiology, School of Public Health, Rutgers UniversitySasha Stanton - University of WashingtonBruce Haffty - Rutgers Cancer Institute of New JerseyWenwei Hu - Rutgers Cancer Institute of New JerseyYibin Kang - Princeton UniversityShi Wei - University of Alabama at BirminghamLanjing Zhang - Department of Pathology, Princeton Medical Center Rutgers Cancer Institute of New Jersey Department of Biological Sciences, Rutgers University Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers University
- Resource Type
- Journal article
- Publication Details
- American journal of cancer research, Vol.11(6), pp.3201-3211
- Publisher
- e-Century Publishing Corporation
- PMID
- 34249455
- PMCID
- PMC8263668
- ISSN
- 2156-6976
- eISSN
- 2156-6976
- Language
- English
- Date published
- 06/15/2021
- Academic Unit
- Epidemiology
- Record Identifier
- 9984364653602771
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