Changing trends in the clinical course and outcome of bacterial keratitis at King Khaled Eye Specialist Hospital

Ali Al-Shehri; Sabah Jastaneiah; Michael D Wagoner

doi:10.1007/s10792-008-9206-6

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Changing trends in the clinical course and outcome of bacterial keratitis at King Khaled Eye Specialist Hospital

Journal article

Peer reviewed

Changing trends in the clinical course and outcome of bacterial keratitis at King Khaled Eye Specialist Hospital

Ali Al-Shehri, Sabah Jastaneiah and Michael D Wagoner

International ophthalmology, Vol.29(3), pp.143-152

06/2009

DOI: 10.1007/s10792-008-9206-6

PMID: 18385946

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Abstract

To evaluate changes in the predisposing factors and causative organisms, clinical course, and outcome of bacterial keratitis at King Khaled Eye Specialist Hospital (KKESH) between 1995 and 2005. Retrospective review of 78 and 103 cases of culture-positive bacterial keratitis admitted to KKESH in 1995 and 2005. Main outcome measures Microbiological cure, visual outcome. There was little change in the predisposing factors for bacterial keratitis, initial clinical severity, or the microbiological profile between 1995 and 2005. While similar topical fortified antibiotic therapy regimens were used in both 1995 and 2005, there was a significant increase in the use of topical corticosteroids in 2005 (P < 0.001), either alone or in combination with medroxyprogesterone 1% and doxycycline. There were significant improvements in the percentage of eyes achieving microbiological cure with medical therapy alone (76.0 vs. 92.2%, P = 0.002) or in combination with surgical intervention (92.4 vs. 100.0%; P = 0.005). The percentage of eyes requiring enucleation or evisceration due to treatment failure declined significantly from 7.6 to 0% (P = 0.006). There was a significant improvement in the percentage of eyes achieving a final visual acuity > or =20/40 (10.1 vs. 29.1%, P = 0.001). Significantly better clinical outcomes were achieved in 2005 compared to 1995. Increased emphasis on management of inflammation in conjunction with the infectious process may have contributed to the improved outcomes.

Corneal Transplantation

Humans

Keratitis - surgery

Middle Aged

Child, Preschool

Hospitals, Special - trends

Infant

Male

Treatment Outcome

Adrenal Cortex Hormones - therapeutic use

Visual Acuity

Saudi Arabia

Bacterial Infections - complications

Adolescent

Keratitis - etiology

Aged, 80 and over

Adult

Female

Aged

Child

Keratitis - drug therapy

Details

Title: Subtitle: Changing trends in the clinical course and outcome of bacterial keratitis at King Khaled Eye Specialist Hospital
Creators: Ali Al-Shehri - Department of Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh, Kingdom of Saudi Arabia
Sabah Jastaneiah
Michael D Wagoner
Resource Type: Journal article
Publication Details: International ophthalmology, Vol.29(3), pp.143-152
Publisher: Netherlands
DOI: 10.1007/s10792-008-9206-6
PMID: 18385946
ISSN: 0165-5701
eISSN: 1573-2630
Language: English
Date published: 06/2009
Academic Unit: Ophthalmology and Visual Sciences
Record Identifier: 9983979936302771

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